1: 100 percent / diethyl phosphorocyanidate, TEA / dimethylformamide / 2 h / 0 °C 2: 98 percent / trifluoroacetic acid / CH2Cl2 / 3 h / Ambient temperature 3: 83 percent / N-iodosuccinimide / dimethylformamide / 12 h / 36 °C 4: 92 percent / n-Bu3SnH / benzene / 0.5 h / Heating 5: 100 percent / 6N aq. HCl / 5 h / Heating View Scheme

chromium(VI) oxide; sulfuric acid in water; acetone T=20°C; Jones oxidation; 0.5 h;

tetra-n-butylammonium tetrafluoroborate; [Ni(2,2'-bipyridine)3(2+)][BF4(1-)]2 in N,N-dimethyl-formamide T=5°C; 15 h; electrochemical reaction, 50 mA applied between a Mg anode and a carbon fiber cathode; Yield given. Yields of byproduct given;

1: 57 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C 2: 98 percent / CrO3; H2SO4 / acetone; H2O / 0.5 h / 20 °C View Scheme

pig liver esterase in phosphate buffer T=20°C; Title compound not separated from byproducts;

potassium hydroxide; ethanol

hydrogenchloride

暂无反应条件数据

1: 100 percent / diethyl phosphorocyanidate, TEA / dimethylformamide / 2 h / 0 °C 2: 98 percent / trifluoroacetic acid / CH2Cl2 / 3 h / Ambient temperature 3: 83 percent / N-iodosuccinimide / dimethylformamide / 12 h / 36 °C 4: 92 percent / n-Bu3SnH / benzene / 0.5 h / Heating 5: 100 percent / 6N aq. HCl / 5 h / Heating 6: methanol View Scheme