(R)-(-)-3-(4-甲氧基苯基)-1-甲基丙胺合成路线 （共 2 条）
反应条件
1: aq. HBr / 6 h / 80 °C
2: K2CO3 / acetone / 4 h / Heating
3: NaN3 / dimethylformamide / 6 h / 70 °C
4: H2 / Pd/C / ethanol / 20 °C
View Scheme
参考文献
Chattopadhyay, Sunil K.; Srivastava, Sachin; Sashidhara, Koneni V.; Tripathi, Arun K.; Bhattacharya, Asish K.; Negi, Arvind S.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 7 p. 1729 - 1731
反应条件
D-glucopyranose; (R)-alanine; Neosartorya fischeri (R)-selective amine transaminase; pyridoxal 5'-phosphate; Reduced nicotinamide-adenine dinucleotide in water
T=30°C; pH=7.5; aq. sodium phosphate bufferEnzymatic reaction;
参考文献
Schaetzle, Sebastian; Steffen-Munsberg, Fabian; Thontowi, Ahmad; Hoehne, Matthias; Robins, Karen; Bornscheuer, Uwe T.
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 13 p. 2439 - 2445
