反应条件
1.1: tetrafluoroboric acid; sodium nitrite / ethanol; water / 3 h / 0 °C / |Inert atmosphere
1.2: 4 h / 100 °C / |Inert atmosphere
2.1: hydrogenchloride / toluene / 2 h / |Inert atmosphere; |Sealed tube; |Heating
3.1: sulfuric acid; nitric acid / 1 h / 20 - 80 °C / |Inert atmosphere
4.1: tetrahydrofuran / 2.25 h / |Inert atmosphere; |Cooling
View Scheme
参考文献
Regueiro-Ren, Alicia; Xue, Qiufen M.; Swidorski, Jacob J.; Gong, Yi-Fei; Mathew, Marina; Parker, Dawn D.; Yang, Zheng; Eggers, Betsy; D'Arienzo, Celia; Sun, Yongnian; Malinowski, Jacek; Gao, Qi; Wu, Dedong; Langley, David R.; Colonno, Richard J.; Chien, Caly; Grasela, Dennis M.; Zheng, Ming; Lin, Pin-Fang; Meanwell, Nicholas A.; Kadow, John F.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 4 p. 1656 - 1669