反应条件
1.1: toluene-4-sulfonic acid / toluene / 18 h / |Dean-Stark; |Reflux
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium t-butanolate / 1,4-dioxane / 4 h / 70 °C / |Inert atmosphere
3.1: sodium t-butanolate / 1,4-dioxane / 8 h / 70 °C / |Inert atmosphere
4.1: ethanol; water / 18 h / 90 °C
5.1: water; ammonium chloride / ethanol / 3 h / 90 °C
5.2: 3 h / 90 °C
View Scheme
参考文献
Pilgrim, Ben S.; Gatland, Alice E.; McTernan, Charlie T.; Procopiou, Panayiotis A.; Donohoe, Timothy J.
Organic Letters, 2013 , vol. 15, # 24 p. 6190 - 6193
