2-氰基-3-(4-吗啉基)-2-丙烯酸乙酯合成路线 （共 4 条）
反应条件
1: 1-(2-morpholin-4-yl-2-oxoethyl)-4-methylpyridinium chloride With 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide 2: ethyl(ethoxymethylene)cyanoacetate in N,N-dimethyl-formamide T=70°C; 24 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 59, p. 101 - 110
反应条件
in isopropyl alcohol 3 h; Reflux;
参考文献
INDOCO REMEDIES LIMITED; RAJADHYAKSHA, Mangesh, Narayan; KOLEKAR, Shankar, Laxman; BAVISKAR, Anil, Yuvraj; PANANDIKAR, Aditi, Milind
Patent: WO2011/64798 A1, 2011 ;
Location in patent: Page/Page column 7 ;
参考文献
Swaringen, Roy A.; Eaddy, John F.; Henderson, Thomas R.
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 3986 - 3989
反应条件
NH2NH2•xH2O in water T=15 - 45°C; 6 h;
参考文献
INDOCO REMEDIES LIMITED; RAJADHYAKSHA, Mangesh, Narayan; KOLEKAR, Shankar, Laxman; BAVISKAR, Anil, Yuvraj; PANANDIKAR, Aditi, Milind
Patent: WO2011/64798 A1, 2011 ;
Location in patent: Page/Page column 7-8 ;
