3-氨基-4-(甲基氨基)苯羧酸甲酯合成路线 （共 10 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol; ethyl acetate 4 h;
参考文献
TEIJIN LIMITED
Patent: EP1502916 A1, 2005 ;
Location in patent: Page 440 ;
EP 1502916 A1
反应条件
methylamine; palladium monocarbide in methanol
反应条件
1: 79 percent / dimethylformamide / 80 °C 2: 86 percent / H2 / Pd/C / ethanol / 2068.59 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 5 p. 1587 - 1597
反应条件
1: HCl 2: 79 percent / dimethylformamide / 80 °C 3: 86 percent / H2 / Pd/C / ethanol / 2068.59 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 5 p. 1587 - 1597
反应条件
1: K2CO3 / CH2Cl2; H2O / 14 h / 20 °C 2: H2 / Pd/C / 5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 41 p. 7303 - 7306
反应条件
in various solvent(s) T=130°C; 1 h;
参考文献
Loev; Musser; Brown; Jones; Kahen; Huang; Khandwala; Sonnino-Goldman; Leibowitz
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 363 - 366
反应条件
in water T=90°C; 3 h;
参考文献
EP1595866 A1, ;
Page/Page column 26 ;
反应条件
16 h; Heating / reflux;
参考文献
WO2003/99814 A1, ;
Page 29 ;
反应条件
1: various solvent(s) / 1 h / 130 °C
2: SOCl2 / toluene; dimethylformamide / 2 h / 130 °C
3: acetonitrile / 2 h / 120 °C
4: various solvent(s) / 0.42 h / 220 - 230 °C
View Scheme
参考文献
Loev; Musser; Brown; Jones; Kahen; Huang; Khandwala; Sonnino-Goldman; Leibowitz
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 363 - 366
反应条件
in dichloromethane
T=20 - 55°C; Product distribution / selectivity;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/69053 A1, 2007 ;
Location in patent: Page/Page column 34 ;
WO 2007/069053 A1
