3-氨基-4-苄氨基苯甲酸合成路线 （共 5 条）
参考文献
Ciba-Geigy
Patent: DD133810DE2733156 , 1979 ;
Chem.Abstr., 1978 , vol. 89, # 61044
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Ciba-Geigy
Patent: DD137939DE2807008 , 19791978 ;
Chem.Abstr., 1979 , vol. 90, # 7597
反应条件
sodium hydroxide in ethanol
1 h; Heating;
参考文献
Goeker, Hakan; Tebrizli, Emin; Abbasoglu, Ufuk
Farmaco, 1996 , vol. 51, # 1 p. 53 - 58
反应条件
1: aq. NaHCO3 / 0.33 h / 150 °C / microwave irradiation
2: H2 / Pd/C / ethyl acetate / 3 h / 20 °C / 760 Torr
View Scheme
参考文献
Semple, Graeme; Skinner, Philip J.; Cherrier, Martin C.; Webb, Peter J.; Sage, Carleton R.; Tamura, Susan Y.; Chen, Ruoping; Richman, Jeremy G.; Connolly, Daniel T.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1227 - 1230
反应条件
1: aq. NaHCO3 / 0.33 h / 150 °C / microwave irradiation
2: H2 / Pd/C / ethyl acetate / 3 h / 20 °C / 760 Torr
View Scheme
参考文献
Semple, Graeme; Skinner, Philip J.; Cherrier, Martin C.; Webb, Peter J.; Sage, Carleton R.; Tamura, Susan Y.; Chen, Ruoping; Richman, Jeremy G.; Connolly, Daniel T.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1227 - 1230
反应条件
1: 89.8 percent / dimethylformamide / 5 h / 80 °C
2: 60.6 percent / NiCl2*6H2O, Zn / methanol / 1 h / Heating
3: 89.7 percent / 10percent NaOH / ethanol / 1 h / Heating
View Scheme
参考文献
Goeker, Hakan; Tebrizli, Emin; Abbasoglu, Ufuk
Farmaco, 1996 , vol. 51, # 1 p. 53 - 58
