6-(吡啶-2-基)-2,3-二氢吡嗪-3-酮合成路线 （共 10 条）
反应条件
1: With hydrogen bromide; acetic acid
T=60°C; 48 h;
2: With sodium hydroxide in water
Reflux; Product distribution / selectivity;
参考文献
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.
Patent: US2010/4443 A1, 2010 ;
Location in patent: Page/Page column 13; 28 ;
反应条件
1: 82 percent / 99percent hydrazine hydrate / aq. ethanol / 2 h / Ambient temperature
2: 89 percent / 10percent HCl / aq. ethanol / 2 h / Heating
View Scheme
参考文献
Baraldi; Bigoni; Cacciari; Caldari; Manfredini; Spalluto
Synthesis, 1994 , # 11 p. 1158 - 1162
反应条件
sodium hydroxide in water; acetic acid
参考文献
American Cyanamid Company
Patent: US4260756 A1, 1981 ;
反应条件
selenium(IV) oxide in various solvent(s)
Heating;
参考文献
Powell, Paul; Sosabowski, Michael H.
Journal of Chemical Research, Miniprint, 1995 , # 8 p. 1840 - 1852
反应条件
1: 86 percent / hydrogen / W-2 Raney nickel / methanol; aq. acetic acid / 5 h / Ambient temperature
2: 82 percent / 99percent hydrazine hydrate / aq. ethanol / 2 h / Ambient temperature
3: 89 percent / 10percent HCl / aq. ethanol / 2 h / Heating
View Scheme
参考文献
Baraldi; Bigoni; Cacciari; Caldari; Manfredini; Spalluto
Synthesis, 1994 , # 11 p. 1158 - 1162
反应条件
hydrogenchloride in ethanol
2 h; Heating;
参考文献
Baraldi; Bigoni; Cacciari; Caldari; Manfredini; Spalluto
Synthesis, 1994 , # 11 p. 1158 - 1162
反应条件
1: aq. N2H4 / Heating
2: 58 percent / SeO2 / various solvent(s) / Heating
View Scheme
参考文献
Powell, Paul; Sosabowski, Michael H.
Journal of Chemical Research, Miniprint, 1995 , # 10 p. 2422 - 2434
反应条件
1: potassium carbonate / water
2: acetic acid; hydrazine / 100 °C
View Scheme
参考文献
Xing, Xuechao; Chang, Ling-Chu; Kong, Qiongman; Colton, Craig K.; Lai, Liching; Glicksman, Marcie A.; Lin, Chien-Liang Glenn; Cuny, Gregory D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5774 - 5777
反应条件
acetic acid; hydrazine
T=100°C;
参考文献
Xing, Xuechao; Chang, Ling-Chu; Kong, Qiongman; Colton, Craig K.; Lai, Liching; Glicksman, Marcie A.; Lin, Chien-Liang Glenn; Cuny, Gregory D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5774 - 5777
反应条件
potassium carbonate; hydrazine hydrate; acetic acid
1) water, r.t., 2) reflux; Yield given. Multistep reaction;
参考文献
Coates; McKillop
Synthesis, 1993 , # 3 p. 334 - 342
