3,4,5-三乙酸基苯甲酸合成路线 （共 14 条）
反应条件
4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide in dichloromethane 3 h; Ambient temperature;
参考文献
Walsh; Wang; Bagan; Wislocki; Miwa
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 150 - 156
参考文献
Fischer,E.; Bergmann
Chemische Berichte, 1919 , vol. 52, p. 839,840
参考文献
Fischer,E.; Bergmann; Lipschitz
Chemische Berichte, 1918 , vol. 51, p. 58
反应条件
1: 91 percent / thionyl chloride / 1 h / 85 °C 2: 81 percent / CHCl3; diethyl ether / 0.5 h / -10 °C 3: 87 percent / hydrogen chloride / dioxane; diethyl ether / 0.5 h / 10 °C 4: 75 percent / acetic acid; potassium acetate; H2SO4 / 3 h / 100 °C 5: hydrogen chloride; ethanol / ethyl acetate / 25 h 6: 220 mg / sodium hydroxide / H2O / 2.25 h / 0 - 20 °C View Scheme
参考文献
Kraus, Michael; Biskup, Ellen; Richling, Elke; Schreier, Peter
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 13 p. 1151 - 1162
反应条件
diborane in tetrahydrofuran 1.) 1 h, 0 deg C; 2.) 30 min, room temp.;
参考文献
Schmidt, Ulrich; Wild, Jochen
Liebigs Annalen der Chemie, 1985 , # 9 p. 1882 - 1894
反应条件
1: phosphorus pentachloride 2: xylene; hydrogen; palladium barium sulfate 3: potassium acetate; alcohol View Scheme
参考文献
Rosenmund; Zetzsche
Chemische Berichte, 1918 , vol. 51, p. 598
反应条件
piperidine; ethanol anschliessendes Erwaermen mit wss. Alkalilauge;
参考文献
Nierenstein
Journal of the American Chemical Society, 1930 , vol. 52, p. 4012
反应条件
sulfuric acid
T=21 - 75°C;
参考文献
Ye, Junju; Abiman, Poobalasingam; Crossley, Alison; Jones, John H.; Wildgoose, Gregory G.; Compton, Richard G.
Langmuir, 2010 , vol. 26, # 3 p. 1776 - 1785
反应条件
pyridine; formic acid; acetic anhydride in ethyl acetate
参考文献
MONASH UNIVERSITY
Patent: US2012/52757 A1, 2012 ;
参考文献
Fischer,E.; Bergamnn; Lipschitz
Chemische Berichte, 1918 , vol. 51, p. 53 Anm. 2
