2-氨基-3-硝基-4-甲基吡啶合成路线 （共 22 条）
反应条件
sulfuric acid; water; sodium nitrite T=0°C; Reflux;
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
Location in patent: Page/Page column 7 ;
反应条件
hydrogen; 5 Pd(II)/C(eggshell) in methanol T=20°C; P=760.051 Torr; 2 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.; DISCH, Jeremy, S.
Patent: WO2010/88574 A1, 2010 ;
Location in patent: Page/Page column 123 ;
WO 2010/088574 A1
反应条件
1: 92 percent / ethanol / 4 h / Heating 2: 39 percent / Br2 / acetic acid / 3 h / 20 °C View Scheme
参考文献
Gueiffier; Milhavet; Blache; Chavignon; Teulade; Madesclaire; Viols; Dauphin; Chapat
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2352 - 2356
反应条件
bromine; acetic acid T=15 - 20°C; 1.66667 - 2.25 h;
参考文献
Liu, Wansheng; Patel, Sunil S.; Cuniere, Nicolas; Lear, Yvonne; Deshpande, Prashant P.; Simon, Jeffrey N.; Lai, Chiajen; Pullockaran, Annie J.; Soundararajan, Nachimuthu; Bien, Jeffrey T.
Patent: US2007/32503 A1, 2007 ;
Location in patent: Page/Page column 8-9; 10 ;
反应条件
2: phosphoryl chloride 3: acetic acid; sodium acetate; palladium/charcoal / Hydrogenation 4: ethyl nitrite; petroleum ether / Diazotization 5: KMnO4; H2O 6: SOCl2 / Erwaermen des Reaktionsgemisches mit Aethanol View Scheme
参考文献
Roe; Seligman
Journal of Organic Chemistry, 1955 , vol. 20, p. 1729,1731
反应条件
1: water; sodium nitrite; sulfuric acid / 0 °C / Reflux 2: trichlorophosphate / 4 h / Reflux 3: potassium dichromate; sulfuric acid / 8 h / 60 °C View Scheme
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
反应条件
N-chloro-succinimide in acetonitrile T=70°C;
参考文献
AVENTIS AGRICULTURE; MERIAL LIMITED; Soll, Mark David; Le Hir de Fallois, Loic Patrick; Huber, Scot Kevin; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Jacobs, Robert Toms
Patent: US2014/80862 A1, 2014 ;
Location in patent: Paragraph 0749 ;
反应条件
1: H2 / 10percent Pd/C / methanol / 760 Torr 2: polyphosphoric acid / 80 - 90 °C 3: 1.) NaH / 1.) DMF, 25 deg C, 20 min 4: HCOOH / 12 h / 25 °C View Scheme
参考文献
Mantlo, Nathan B.; Chakravarty, Prasun K.; Ondeyka, Debra L.; Siegl, Peter K. S.; Chang, Raymond S.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2919 - 2922
反应条件
iron; ytterbium(III) triflate T=75°C; 3 h;
参考文献
Wang, Fen; Tran-Dube, Michelle; Scales, Stephanie; Johnson, Sarah; McAlpine, Indrawan; Ninkovic, Sacha
Tetrahedron Letters, 2013 , vol. 54, # 31 p. 4054 - 4057
反应条件
1: With hydrogenchloride in water T=-15°C; 2: With sodium nitrite in water T=-10 - 20°C;
参考文献
Linz, Sabine; Mueller, Joerg; Huebner, Harald; Gmeiner, Peter; Troschuetz, Reinhard
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 13 p. 4448 - 4458
