5-苯基-1H-吡咯-2-羧酸合成路线 （共 9 条）
反应条件
T=152 - 185°C; differential thermal analysis (DTAmax given)) also of other 2-pyrrolecarboxylic acids;
参考文献
Sobenina, L. N.; Sergeeva, M. P.; Mikhaleva, A. I.; Sigalov, M. V.; Korostova, S. E.; et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1990 , vol. 26, # 5 p. 516 - 520
Khimiya Geterotsiklicheskikh Soedinenii, 1990 , # 5 p. 612 - 616
反应条件
sodium hydroxide; bunazosin in methanol; dichloromethane; ethyl acetate
参考文献
Merck and Co., Inc.; Tularik Inc.
Patent: US6306891 B1, 2001 ;
反应条件
sodium hydroxide in ethanol
Heating;
参考文献
Sobenina, L. N.; Sergeeva, M. P.; Mikhaleva, A. I.; Sigalov, M. V.; Korostova, S. E.; et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1990 , vol. 26, # 5 p. 516 - 520
Khimiya Geterotsiklicheskikh Soedinenii, 1990 , # 5 p. 612 - 616
反应条件
1: 83 percent / tetrahydrofuran / -40 °C
2: 93 percent / TFA / CH2Cl2
3: 1.) DDQ; 2.) 10percent NaOH / 1.) CH2Cl2, rt., 1 h; 2.) reflux, 12 h
View Scheme
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Rubio, Almudena; Valenciano, Jesus; Garcia Navio, Jose Luis; Alvarez-Builla, Julio; Vaquero, Juan Jose
Tetrahedron Letters, 1993 , vol. 34, # 39 p. 6317 - 6320
反应条件
1: 93 percent / TFA / CH2Cl2
2: 1.) DDQ; 2.) 10percent NaOH / 1.) CH2Cl2, rt., 1 h; 2.) reflux, 12 h
View Scheme
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Rubio, Almudena; Valenciano, Jesus; Garcia Navio, Jose Luis; Alvarez-Builla, Julio; Vaquero, Juan Jose
Tetrahedron Letters, 1993 , vol. 34, # 39 p. 6317 - 6320
反应条件
Erwaermen des Reaktionsprodukts mit aethanol. KOH;
参考文献
Blicke et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 1675
反应条件
1: With water; sodium hydroxide
T=100°C;
2: With water; acetic acid
T=20°C;
参考文献
Luisa, C. Lopez-Cara; De Las Infantas, M. Jose Pineda; Carrion, M. Dora; Camacho, M. Encarnacion; Gallo, Miguel A.; Espinosa, Antonio; Entrena, Antonio
Magnetic Resonance in Chemistry, 2009 , vol. 47, # 12 p. 1101 - 1109
反应条件
sodium hydroxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone
1.) CH2Cl2, rt., 1 h; 2.) reflux, 12 h; Yield given. Multistep reaction;
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Rubio, Almudena; Valenciano, Jesus; Garcia Navio, Jose Luis; Alvarez-Builla, Julio; Vaquero, Juan Jose
Tetrahedron Letters, 1993 , vol. 34, # 39 p. 6317 - 6320
反应条件
thionyl chloride in toluene
参考文献
Micheli, Fabrizio; Di Fabio, Romano; Giacometti, Angelo; Roth, Adelheid; Moro, Elisa; Merlo, Giancarlo; Paio, Alfredo; Merlo-Pich, Emilio; Tomelleri, Silvia; Tonelli, Federica; Zarantonello, Paola; Zonzini, Laura; Capelli, Anna Maria
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7308 - 7311
