6-氯-2-吡啶羧酸甲酯合成路线 （共 15 条）
反应条件
hydrogenchloride; n-butyllithium Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organometallic Chemistry, , vol. 186, # 2 p. 147 - 153
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-45 - 0°C; 1.5 h; 2: With sodium hydroxide; water in tetrahydrofuran
参考文献
LG LIFE SCIENCES, LTD.
Patent: WO2007/58482 A1, 2007 ;
Location in patent: Page/Page column 47-48 ;
WO 2007/058482 A1
反应条件
pyridine; Copper(I)chloride in anhydrous xylene; diethyl ether; dichloromethane
参考文献
Shell Research Limited
Patent: US5384305 A1, 1995 ;
反应条件
1: sodium 3-(trifluoromethyl)phenolate With copper(l) chloride in pyridine; xylene Heating / reflux; 2: methyl 6-chloro-pyridine-2-carboxylate in pyridine; xylene 14 h; Heating / reflux;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: EP1207154 A1, 2002 ;
Location in patent: Example 1 ;
参考文献
Cava; Bhattacharyya
Journal of Organic Chemistry, 1958 , vol. 23, p. 1287
