7-甲基-2-(吗啉-4-基)-9-[1-(苯氨基)乙基]吡啶并[1,2-a]嘧啶-4-酮合成路线 （共 6 条）
反应条件
1: in toluene 4 h; Heating / reflux; 2: With sodium tetrahydroborate in toluene T=0 - 20°C; 1 h;
参考文献
WO2004/16607 A1, ;
Page 30 ;
WO 2004/016607 A1
反应条件
1.1: dichloromethane / 20 °C 2.1: methanesulfonyl chloride; triethylamine 3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine 3.2: 20 °C 4.1: toluene / 4 h / Reflux; Molecular sieve; Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C View Scheme
参考文献
Molecular Pharmaceutics, , vol. 8, # 3 p. 901 - 912
反应条件
1.1: methanesulfonyl chloride; triethylamine 2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine 2.2: 20 °C 3.1: toluene / 4 h / Reflux; Molecular sieve; Inert atmosphere 4.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C View Scheme
参考文献
Molecular Pharmaceutics, , vol. 8, # 3 p. 901 - 912
反应条件
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine 1.2: 20 °C 2.1: toluene / 4 h / Reflux; Molecular sieve; Inert atmosphere 3.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C View Scheme
参考文献
Molecular Pharmaceutics, , vol. 8, # 3 p. 901 - 912
反应条件
1: triethylamine / dichloromethane / 0 - 22 °C 2: triethylamine / Reflux View Scheme
参考文献
Molecular Pharmaceutics, , vol. 9, # 6 p. 1705 - 1716
反应条件
triethylamine Reflux;
参考文献
Molecular Pharmaceutics, , vol. 9, # 6 p. 1705 - 1716
