2-(2-碘苯基)乙酸甲酯合成路线 （共 19 条）
反应条件
1: aq. NaOH 2: SOCl2 3: H2O2, aq. NaOH 4: acetone View Scheme
参考文献
Leffler,J.E.; Wilson,A.F.
Journal of Organic Chemistry, 1960 , vol. 25, p. 424 - 428
反应条件
1: aq. NaOH 2: SOCl2 3: H2O2, aq. NaOH 4: SOCl2 View Scheme
参考文献
Leffler,J.E.; Wilson,A.F.
Journal of Organic Chemistry, 1960 , vol. 25, p. 424 - 428
反应条件
copper; potassium carbonate in pyridine 6 h; Heating;
参考文献
Sawyer; Bach; Baker; Baldwin; Borromeo; Cockerham; Fleisch; Floreancig; Froelich; Jackson; Marder; Palkowitz; Roman; Saussy Jr.; Schmittling; Silbaugh; Spaethe; Stengel; Sofia
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4411 - 4432
反应条件
L-proline in N,N-dimethyl-formamide T=20 - 120°C; Inert atmosphere;
参考文献
Mei, Tian-Sheng; Wang, Dong-Hui; Yu, Jin-Quan
Organic Letters, 2010 , vol. 12, # 14 p. 3140 - 3143
参考文献
Leffler,J.E.; Wilson,A.F.
Journal of Organic Chemistry, 1960 , vol. 25, p. 424 - 428
反应条件
sulfuric acid
T=65°C; 2.5 h;
参考文献
Lachia, Mathilde; Jung, Pierre M.J.; De Mesmaeker, Alain
Tetrahedron Letters, 2012 , vol. 53, # 34 p. 4514 - 4517
反应条件
in methanol; diethyl ether; dichloromethane
T=0°C; 1 h;
参考文献
MERCK and CO., INC.
Patent: WO2008/51532 A1, 2008 ;
Location in patent: Page/Page column 46 ;
反应条件
silver benzoate; triethylamine
T=20°C; Wolff rearrangement; 0.5 h;
参考文献
Deville, Jay P; Behar, Victor
Organic letters, 2002 , vol. 4, # 8 p. 1403 - 1405
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2003/153556 A1, 2003 ;
US 20030153556 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
2 h;
参考文献
VICURON PHARMACEUTICALS INC.
Patent: US2006/211603 A1, 2006 ;
Location in patent: Page/Page column 79 ;
