1-(4-甲基-2-甲基硫代-5-嘧啶基)乙酮合成路线 （共 11 条）
反应条件
hydrogenchloride in ethanol Ambient temperature;
参考文献
Bajnati, Abdelilah; Kokel, Bruno; Hubert-Habart, Michel
Bulletin de la Societe Chimique de France, 1987 , # 2 p. 318 - 324
反应条件
1: conc. hydrochloric acid / methanol / 4 h / Heating 2: NaOH / ethanol / 24 h / Heating View Scheme
参考文献
Menichi; Boutar; Kokel; et al.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 1 p. 275 - 279
反应条件
hydrogenchloride in methanol Heatingovernight;
参考文献
Menichi; Boutar; Kokel; et al.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 1 p. 275 - 279
反应条件
1.1: 71 percent / PCl5 / benzene / 3 h / Heating 2.1: 72 percent / t-BuOK / 2-methyl-propan-2-ol; diethyl ether / 4 h / 20 °C 3.1: cuprous chloride; nC4H9NH2; hydroxylamine hydrochloride / tetrahydrofuran; methanol / 0 °C 3.2: 81 percent / tetrahydrofuran; methanol / 5 h / 10 - 20 °C View Scheme
参考文献
Wang, Jiang-Hong; Shen, Yu-Quan; Yu, Cong-Xuan; Si, Jing-Hai
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 9 p. 1455 - 1460
反应条件
ethanol; sodium ethanolate
Cyclization; Condensation; 2 h;
参考文献
Wang, Jiang-Hong; Shen, Yu-Quan; Yu, Cong-Xuan; Si, Jing-Hai
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 9 p. 1455 - 1460
反应条件
1: (COCl)2 / various solvent(s) / 1 h / 20 °C
2: tetrahydrofuran / 2 h / -78 °C
View Scheme
参考文献
Palanki, Moorthy S.S.; Gayo-Fung, Leah M.; Shevlin, Graziella I.; Erdman, Paul; Sato, Mark; Goldman, Mark; Ransone, Lynn J.; Spooner, Cheryl
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2573 - 2577
反应条件
in tetrahydrofuran
T=-78°C; 2 h;
参考文献
Palanki, Moorthy S.S.; Gayo-Fung, Leah M.; Shevlin, Graziella I.; Erdman, Paul; Sato, Mark; Goldman, Mark; Ransone, Lynn J.; Spooner, Cheryl
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2573 - 2577
反应条件
1: 87.5 percent / acetic anhydride / 3 h / 130 °C
2: 70 percent / EtONa; EtOH / 2 h
View Scheme
参考文献
Wang, Jiang-Hong; Shen, Yu-Quan; Yu, Cong-Xuan; Si, Jing-Hai
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 9 p. 1455 - 1460
反应条件
in methanol
4 h; Heating;
参考文献
Menichi, Gabriel; Naciri, Jaouad; Kokel, Bruno; Hubert-Habart, Michel
Heterocycles, 1984 , vol. 22, # 9 p. 2013 - 2017
反应条件
hydrazine hydrate in methanol
16 h; Heating;
参考文献
Menichi; Boutar; Kokel; et al.
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 1 p. 275 - 279
