反应条件
1: 4-amino-2-ethylsulfanylpyrimidine-5-carboxylic acid With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=0°C; 0.25 h;
2: O,N-dimethyl-hydroxylamine hydrochloride in N,N-dimethyl-formamide
T=0 - 20°C; 2 h;
参考文献
Chu, Xin-Jie; DePinto, Wanda; Bartkovitz, David; So, Sung-Sau; Vu, Binh T.; Packman, Kathryn; Lukacs, Christine; Ding, Qingjie; Jiang, Nan; Wang, Ka; Goelzer, Petra; Yin, Xuefeng; Smith, Melissa A.; Higgins, Brian X.; Chen, Yingsi; Xiang, Qing; Moliterni, John; Kaplan, Gerald; Graves, Bradford; Lovey, Allen; Fotouhi, Nader
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6549 - 6560