反应条件
1: 3-carboxyazetidine-1-carboxylic acid tert-butyl ester With dicyclohexyl-carbodiimide in tetrahydrofuran
T=20°C;
2: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in tetrahydrofuran; acetonitrile
T=20°C; 24 h;
参考文献
PFIZER LIMITED; ACIRO, Caroline; BAGAL, Sharanjeet Kaur; HARVEY, John Wilson; JONES, Lyn Howard; MOWBRAY, Charles Eric; OWEN, Robert McKenzie; SABNIS, Yogesh Anil; STORER, Robert Ian; YEAP, Siew Kuen
Patent: WO2010/131145 A1, 2010 ;
Location in patent: Page/Page column 86 ;