N-Boc-4-氨基甲基苯甲腈合成路线 （共 22 条）
反应条件
hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine in methanol 12 h; Reflux;
参考文献
Kwiatkowska, Anna; Couture, Frederic; Levesque, Christine; Ly, Kevin; Desjardins, Roxane; Beauchemin, Sophie; Prahl, Adam; Lammek, Bernard; Neugebauer, Witold; Dory, Yves L.; Day, Robert
Journal of Medicinal Chemistry, 2014 , vol. 57, # 1 p. 98 - 109
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 49 h; Inert atmosphere; 2: With water; sodium hydroxide T=0°C; 0.25 h; Inert atmosphere;
参考文献
Mok, N. Yi; Chadwick, James; Kellett, Katherine A. B.; Casas-Arce, Eva; Hooper, Nigel M.; Johnson, A. Peter; Fishwick, Colin W. G.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 5 p. 1843 - 1852
反应条件
1: 4-Cyanobenzylamine Hydrochloride With sodium hydroxide in water
T=25 - 28°C; pH=> 12;
2: di-tert-butyl dicarbonate in methanol; water
T=25 - 30°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/90153 A1, 2006 ;
Location in patent: Page/Page column 15-16 ;
反应条件
triethylamine in dichloromethane
T=20°C; Inert atmosphere;
参考文献
Willems, Lianne I.; Li, Nan; Florea, Bogdan I.; Ruben, Mark; Van Der Marel, Gijsbert A.; Overkleeft, Herman S.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 18 p. 4431 - 4434
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 16 h; Inert atmosphere;
参考文献
Mok, N. Yi; Chadwick, James; Kellett, Katherine A. B.; Casas-Arce, Eva; Hooper, Nigel M.; Johnson, A. Peter; Fishwick, Colin W. G.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 5 p. 1843 - 1852
反应条件
sodium hydroxide in tetrahydrofuran; methanol; water
参考文献
Eli Lilly and Company
Patent: US5726159 A1, 1998 ;
US 5726159 A
Title/Abstract Full Text Show Details
Eli Lilly and Company
Patent: US5914319 A1, 1999 ;
US 5914319 A
Title/Abstract Full Text Show Details
Eli Lilly and Company
Patent: US5707966 A1, 1998 ;
US 5707966 A
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium carbonate in water; toluene
T=85°C; Suzuki-Miyaura cross-coupling reaction; 22 h; Inert atmosphere;
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2011 , vol. 13, # 15 p. 3956 - 3959
反应条件
C45H59ClNPPd; potassium carbonate in water; tert-butyl alcohol
T=85°C; Suzuki-Miyaura Coupling; 3 h; Inert atmosphere;
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2013 , vol. 15, # 10 p. 2534 - 2537
反应条件
sodium hydroxide in 1,4-dioxane
T=20°C; 16 h;
参考文献
NOVARTIS AG
Patent: WO2008/37476 A1, 2008 ;
Location in patent: Page/Page column 12 ;
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; dichloro(cycloocta-1,5-diene)palladium(II) in water; tert-butyl alcohol
T=95°C; Suzuki-Miyaura cross-coupling; 22 h; Inert atmosphere;
参考文献
Molander, Gary A.; Shin, Inji
Organic Letters, 2012 , vol. 14, # 12 p. 3138 - 3141
