(S)-(-)-1-(4-氟苯基)乙胺合成路线 （共 17 条）
反应条件
hydrogen; palladium on activated carbon in methanol T=60 - 100°C; P=3750.38 - 6000.6 Torr; 21 h; Heating;
参考文献
US6797842 B2, ;
Page column 28-29 ;
反应条件
hydrogen; palladium on activated charcoal in methanol; acetic acid T=60°C; P=3750.3 Torr; 12 h;
参考文献
Kanai, Masatomi; Yasumoto, Manabu; Kuriyama, Yokusu; Inomiya, Kenjin; Katsuhara, Yutaka; Higashiyama, Kimio; Ishii, Akihiro
Chemistry Letters, 2004 , vol. 33, # 11 p. 1424 - 1425
反应条件
1: With C9H16BNO in tetrahydrofuran T=20°C; 24 h; 2: With borane-THF in tetrahydrofuran 24 h; Reflux; optical yield given as percent eeenantioselective reactionFurther stages;
参考文献
Tetrahedron Asymmetry, , vol. 23, # 9 p. 716 - 721
反应条件
pyridoxal 5'-phosphate in aq. phosphate buffer; dimethyl sulfoxide T=30°C; pH=7.5; 24 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Process Biochemistry, , vol. 48, # 10 p. 1488 - 1494
反应条件
Novozym 435 T=23°C; 3 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 23, # 3-4 p. 230 - 236
反应条件
1: With (Ph)2SiH2; silver trifluoromethanesulfonate in tetrahydrofuran T=20°C; 25 h; 2: With hydrogenchloride in tetrahydrofuran; methanol Further stages. Title compound not separated from byproducts.;
参考文献
Chemical Communications, , # 22 p. 2360 - 2361
反应条件
1: With (SP)-O-ethylphenylphosphonothioic acid in diethyl ether T=20°C; 6 h; 2: With potassium hydroxide
参考文献
Organic Letters, , vol. 6, # 23 p. 4227 - 4230
反应条件
1: 100 percent / ZnCl2 / toluene / 15 h / Heating 2: NaBH4 / methanol / 12 h / 0 °C 3: 98 percent / H2 / Pd/C / methanol; acetic acid / 12 h / 60 °C / 3750.3 Torr View Scheme
参考文献
Chemistry Letters, , vol. 33, # 11 p. 1424 - 1425
反应条件
1: With ammonium acetate; sodium cyanoborohydride in methanol T=20°C; reductive amination; 2: racemate resolution; Further stages. Title compound not separated from byproducts.;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 7 p. 1339 - 1347
反应条件
1: NaBH4 / methanol / 12 h / 0 °C 2: 98 percent / H2 / Pd/C / methanol; acetic acid / 12 h / 60 °C / 3750.3 Torr View Scheme
参考文献
Chemistry Letters, , vol. 33, # 11 p. 1424 - 1425
