4 -溴- 2 - 碘苯甲胺合成路线 （共 23 条）
反应条件
N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate in methanol; dichloromethane 8 h; Ambient temperature;
参考文献
Kajigaeshi, Shoji; Kakinami, Takaaki; Yamasaki, Hiromichi; Fujisaki, Shizuo; Okamoto, Tsuyoshi
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 2 p. 600 - 602
反应条件
ammonium heptamolybdate; sodium perborate; acetic acid; potassium bromide T=0 - 20°C; 3 h;
参考文献
WYETH
Patent: WO2004/50631 A1, 2004 ;
Location in patent: Page 116 ;
反应条件
1: With n-butyllithium in diethyl ether; hexane T=-78°C; 1 h; 2: With poly[4-(dibutyliodostannyl)butyl]styrene in diethyl ether; hexane T=20°C; 18 h; 3: With bromine in diethyl ether; hexane; dichloromethane T=-78 - 20°C; 2 h;
参考文献
Chretien, Jean-Mathieu; Zammattio, Francoise; Le Grognec, Erwan; Paris, Michael; Cahingt, Blanche; Montavon, Gilles; Quintard, Jean-Paul
Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2870 - 2873
反应条件
sodium perborate; ammonium heptamolybdate; potassium bromide in acetic acid T=20°C; Bromination; 2.2 h;
参考文献
Tetrahedron Letters, , vol. 41, # 13 p. 2083 - 2085
反应条件
mercury(II) diacetate; iodine in dichloromethane T=25°C; 12 h; Overall yield = 35 percent;
参考文献
Australian Journal of Chemistry, , vol. 66, # 12 p. 1570 - 1575
反应条件
1: trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane; NH4Br / acetonitrile / 0.25 h / 20 °C 2: NH4I; trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane / acetonitrile / 4 h / 20 °C View Scheme
参考文献
Journal of the Iranian Chemical Society, , vol. 9, # 3 p. 321 - 326
反应条件
1.1: HCl; NaNO2 / acetonitrile; H2O / 0.5 h / -5 - -2 °C 1.2: 2.06 g / K2CO3 / acetonitrile; H2O / 0 - 20 °C 2.1: PdCl2(P(C6H5)3)2; CuI; triethylamine / 20 °C 3.1: 780 mg / K2CO3 / tetrahydrofuran; methanol / 4 h / 20 °C 4.1: 98 percent / 1,2-dichloro-benzene / 200 °C View Scheme
参考文献
Kimball, David B.; Weakley, Timothy J. R.; Haley, Michael M.
Journal of Organic Chemistry, 2002 , vol. 67, # 18 p. 6395 - 6405
反应条件
CaO; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene in N,N-dimethyl-formamide T=60°C; 1 h;
参考文献
Chemistry Letters, , p. 839 - 840
反应条件
1: dimethylformamide / 0.5 h / 20 °C 2: dimethylformamide / 0.5 h / 100 °C 3: aq. K2CO3 / methanol / 12 h / 20 °C View Scheme
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
反应条件
copper(l) iodide; trans-N,N'-dimethylcyclohexane-1,2-diamine; caesium carbonate in 1,4-dioxane T=100°C; Inert atmosphere;
参考文献
Huang, Wei-Sheng; Xu, Rongsong; Dodd, Rory; Shakespeare, William C.
Tetrahedron Letters, 2013 , vol. 54, # 38 p. 5214 - 5216
