4 -溴- 2 - 碘苯甲胺合成路线 （共 23 条）
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine in N,N-dimethyl acetamide
T=20°C; Sonogashira Cross-Coupling; 1 h;
2: With sodium hydroxide in N,N-dimethyl acetamide
T=140°C;
参考文献
Yu, Xufen; Park, Eun-Jung; Kondratyuk, Tamara P.; Pezzuto, John M.; Sun, Dianqing
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 44 p. 8835 - 8847
反应条件
1: 53 percent / PdCl2(PPh3)2; CuI; Et3N / 25 h / Heating
2: 83 percent / Cu(OCOCF3)2*xH2O / 1,2-dichloro-ethane / 4 h / Heating
View Scheme
参考文献
Hiroya, Kou; Itoh, Shin; Sakamoto, Takao
Journal of Organic Chemistry, 2004 , vol. 69, # 4 p. 1126 - 1136
反应条件
copper(I) oxide; caesium carbonate in 1,4-dioxane; N,N-dimethyl-formamide
T=90°C; 6 h; Inert atmosphere;
参考文献
Guo, Han; Liu, Jin; Wang, Xianxue; Huang, Guosheng
Synlett, 2012 , vol. 23, # 6 p. 903 - 906
