3-溴-4-甲基三氟甲苯合成路线 （共 11 条）
反应条件
N-bromosuccinmide; sulfuric acid; trifluoroacetic acid T=20°C; 20 h;
参考文献
SENSORS FOR MEDICINE AND SCIENCE, INC.
Patent: WO2008/66921 A2, 2008 ;
Location in patent: Page/Page column 69-70 ;
反应条件
bromine; iron in dichloromethane 24 h; Ambient temperature;
参考文献
Kira, Mitsuo; Miyazawa, Takashi; Sugiyama, Hisashi; Yamaguchi, Munehiro; Sakurai, Hideki
Journal of the American Chemical Society, 1993 , vol. 115, # 8 p. 3116 - 3124
反应条件
sulfur(IV) fluoride in hydrogen fluoride T=70°C; 20 h;
参考文献
Nishida, Masakazu; Hosokawa, Kenzo; Ueda, Teruo; Aoki, Toshiki; Muramatsu, Hiroshige
Journal of Fluorine Chemistry, 1989 , vol. 43, p. 35 - 52
反应条件
1: H2, HClO4, AcOH / Pd-C 2: Br2, Fe / CCl4 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 43, p. 2941 - 2946
反应条件
1: LiAlH4 / diethyl ether 2: H2, HClO4, AcOH / Pd-C 3: Br2, Fe / CCl4 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 43, p. 2941 - 2946
反应条件
hydrogen fluoride; bromine
反应条件
in ice-water; dimethyl sulfoxide
反应条件
hydrogenchloride; sodium hydrogen sulphate in pyridine
参考文献
Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Doherty, Elizabeth M.; Fotsch, Christopher H.; Han, Nianhe; Kelly, Michael G.; Liu, Qingyian; Norman, Mark Henry; Ognyanov, Vassil I.; Wang, Xianghong; Zhu, Jiawang
Patent: US2003/195201 A1, 2003 ;
US 20030195201 A1
反应条件
1: With 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; palladium diacetate in DMF (N,N-dimethyl-formamide); water
T=100°C; 18 h;
2: With hydrogenchloride; water in DMF (N,N-dimethyl-formamide); water
T=20°C;
参考文献
CYTOKINETICS, INC.
Patent: WO2005/5382 A2, 2005 ;
Location in patent: Page 55 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in benzene
16 h; Reflux;
参考文献
Chakravarty, Devraj; Kreutter, Kevin; Powell, Mark; Shook, Brian; Song, Fengbin; Xu, Guozhang; Yang, Shyh-Ming; Zhang, Rui; Zhao, Bao-Ping
Patent: US2012/302610 A1, 2012 ;
Location in patent: Page/Page column 39 ;
US 20120302610 A1
