(6-溴-1,3-苯并二氧代l-5-基)甲醇合成路线 （共 37 条）
反应条件
methanol; sodium methylate
参考文献
Journal of Organic Chemistry, , vol. 23, p. 1012
反应条件
sodium methylate; dimethyl sulfoxide T=150°C; 0.0194444 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Imakura, Yasuhiro; Okimoto, Kazuto; Gorohata, Chizuru; Kobayashi, Shigeru; Kihara, Masaru; Yamashita, Shinsuke
Heterocycles, 1990 , vol. 31, # 6 p. 1067 - 1076
反应条件
1: acetic acid 2: sodium methylate; methanol View Scheme
参考文献
Journal of Organic Chemistry, , vol. 23, p. 1012
反应条件
diisobutylaluminium hydride; chloromethyl methyl ether; N-ethyl-N,N-diisopropylamine 1) CH2Cl2, room temperature, 4 h, 2) THF, toluene, a) -78 deg C to 0 deg C, b) 0 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 34, # 31 p. 4893 - 4896
反应条件
dimethyl sulfoxide T=150°C; 0.0194444 h; other sodium alkoxide - alcohol (or phenol) systems and sodium alkoxide - alcohol - alcohol (or phenol) systems; various temperatures and reaction times; Product distributionMechanism;
参考文献
Imakura, Yasuhiro; Okimoto, Kazuto; Gorohata, Chizuru; Kobayashi, Shigeru; Kihara, Masaru; Yamashita, Shinsuke
Heterocycles, 1990 , vol. 31, # 6 p. 1067 - 1076
反应条件
bis(1,5-cyclooctadiene)nickel (0) in N,N-dimethyl-formamide
参考文献
Semmelhack, M.F.; Helquist, Paul; Jones, L.D.; Keller, Leonard; Mendelson L.; et al.
Journal of the American Chemical Society, 1981 , vol. 103, # 21 p. 6460 - 6471
反应条件
1: 4-bromo-5-hydroxymethyl-1,2-methylenedioxybenzene With n-butyllithium in tetrahydrofuran; hexane 1 h; 2: piperonal in tetrahydrofuran; hexane T=-78°C; 0.666667 h;
参考文献
Flanagan, Stuart R; Harrowven, David C; Bradley, Mark
Tetrahedron, 2002 , vol. 58, # 30 p. 5989 - 6001
反应条件
1: 4-bromo-5-hydroxymethyl-1,2-methylenedioxybenzene With n-butyllithium in tetrahydrofuran; hexane 1 h; 2: 3,4-dimethoxy-benzaldehyde in tetrahydrofuran; hexane 0.666667 h;
参考文献
Flanagan, Stuart R; Harrowven, David C; Bradley, Mark
Tetrahedron, 2002 , vol. 58, # 30 p. 5989 - 6001
参考文献
Hara, Hiroshi; Satoh, Hiroya; Hoshino, Osamu
Heterocycles, 1992 , vol. 33, # 1 p. 43 - 46
反应条件
pyridinium p-toluenesulfonate in dichloromethane Ambient temperature;
参考文献
Rigby, James H.; Cavezza, Alexandre; Heeg, Mary Jane
Journal of the American Chemical Society, 1998 , vol. 120, # 15 p. 3664 - 3670
