in pyridine T=0°C; 9 h;

3: tetrahydrofuran / 0.5 h / -78 °C 4: H2, quinoline / Lindlar catalyst / benzene / 2 h / 25 °C 5: DMAP / CH2Cl2 / 2 h / Heating 6: 35 percent / Pd(PPh3)4, Et3N / tetrahydrofuran / 5 h / Heating 7: 25 percent / toluene / 5 h / 220 - 230 °C / in sealed tube 8: 90 percent / OsO4, Me3NO, pyridine / 2-methyl-propan-2-ol; H2O / 18 h / Heating 9: 81 percent / SO3-pyridine, Et3N / 20 h / 20 °C 10: 85 percent / NaTeH / ethanol / 0.5 h / 23 °C 11: 87 percent / t-BuNH3-BH3 / methanol / 21 h / 23 °C 12: 95 percent / TsOH / benzene / 1 h / 23 °C 13: 94 percent / MCPBA / CH2Cl2 / 0.5 h / -25 °C 14: 68 percent / CaCO3 / toluene / 70 h / Heating 15: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C 16: 89 percent / LiAlH4 / diethyl ether / 1 h / Heating 17: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating 18: 83 percent / 1.) OsO4, 2.) H2S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h 19: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C 20: 95 percent / TsOH / CHCl3; methanol / 0.67 h / 20 °C 21: 96 percent / pyridine / 2 h / 20 °C 22: 95 percent / TsOH / 0.25 h / 20 °C 23: 95 percent / LiAlH4 / diethyl ether / 0.17 h / 0 °C 24: 78 percent / SO3-pyridine, Et3N / dimethylsulfoxide / 16 h / 23 °C 25: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C 26: 79 percent / MnO2 / benzene / 3 h / 23 °C 27: 93 percent / diethyl ether / 0.25 h / -78 °C 28: 95 percent / 1.) 3 N HCl - THF, 23 deg C, 1 h, then 0.2 N KOH - THF - MeOH, 23 deg C, 20 min 29: 78 percent / 1.) PhSeCl, 2.) Ra-Ni(W-2) / 1.) CH2Cl2, 0 deg C, 38 h, 2.) EtOH, reflux, 5 min 30: 97 percent / n-Bu4NF / tetrahydrofuran / 5 h / 23 °C 31: 89 percent / n-Bu3P / tetrahydrofuran / 0.5 h / 23 °C 32: 84 percent / 30percent H2O2 / CH2Cl2 / 20 h / 18 °C 33: 96 percent / 1.) DDQ, 2.) K2CO3 / 1.) CH2Cl2 - H2O, 23 deg C, 48 h, 2.) MeOH, 23 deg C, 40 min 34: 77 percent / aq. HClO4; tetrahydrofuran / 60 h / 23 °C 35: 85 percent / pyridine / 9 h / 0 °C View Scheme

2: tetrahydrofuran / 0.5 h / -78 °C 3: H2, quinoline / Lindlar catalyst / benzene / 2 h / 25 °C 4: DMAP / CH2Cl2 / 2 h / Heating 5: 35 percent / Pd(PPh3)4, Et3N / tetrahydrofuran / 5 h / Heating 6: 25 percent / toluene / 5 h / 220 - 230 °C / in sealed tube 7: 90 percent / OsO4, Me3NO, pyridine / 2-methyl-propan-2-ol; H2O / 18 h / Heating 8: 81 percent / SO3-pyridine, Et3N / 20 h / 20 °C 9: 85 percent / NaTeH / ethanol / 0.5 h / 23 °C 10: 87 percent / t-BuNH3-BH3 / methanol / 21 h / 23 °C 11: 95 percent / TsOH / benzene / 1 h / 23 °C 12: 94 percent / MCPBA / CH2Cl2 / 0.5 h / -25 °C 13: 68 percent / CaCO3 / toluene / 70 h / Heating 14: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C 15: 89 percent / LiAlH4 / diethyl ether / 1 h / Heating 16: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating 17: 83 percent / 1.) OsO4, 2.) H2S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h 18: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C 19: 95 percent / TsOH / CHCl3; methanol / 0.67 h / 20 °C 20: 96 percent / pyridine / 2 h / 20 °C 21: 95 percent / TsOH / 0.25 h / 20 °C 22: 95 percent / LiAlH4 / diethyl ether / 0.17 h / 0 °C 23: 78 percent / SO3-pyridine, Et3N / dimethylsulfoxide / 16 h / 23 °C 24: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C 25: 79 percent / MnO2 / benzene / 3 h / 23 °C 26: 93 percent / diethyl ether / 0.25 h / -78 °C 27: 95 percent / 1.) 3 N HCl - THF, 23 deg C, 1 h, then 0.2 N KOH - THF - MeOH, 23 deg C, 20 min 28: 78 percent / 1.) PhSeCl, 2.) Ra-Ni(W-2) / 1.) CH2Cl2, 0 deg C, 38 h, 2.) EtOH, reflux, 5 min 29: 97 percent / n-Bu4NF / tetrahydrofuran / 5 h / 23 °C 30: 89 percent / n-Bu3P / tetrahydrofuran / 0.5 h / 23 °C 31: 84 percent / 30percent H2O2 / CH2Cl2 / 20 h / 18 °C 32: 96 percent / 1.) DDQ, 2.) K2CO3 / 1.) CH2Cl2 - H2O, 23 deg C, 48 h, 2.) MeOH, 23 deg C, 40 min 33: 77 percent / aq. HClO4; tetrahydrofuran / 60 h / 23 °C 34: 85 percent / pyridine / 9 h / 0 °C View Scheme

1: tetrahydrofuran / 0.5 h / -78 °C 2: H2, quinoline / Lindlar catalyst / benzene / 2 h / 25 °C 3: DMAP / CH2Cl2 / 2 h / Heating 4: 35 percent / Pd(PPh3)4, Et3N / tetrahydrofuran / 5 h / Heating 5: 25 percent / toluene / 5 h / 220 - 230 °C / in sealed tube 6: 90 percent / OsO4, Me3NO, pyridine / 2-methyl-propan-2-ol; H2O / 18 h / Heating 7: 81 percent / SO3-pyridine, Et3N / 20 h / 20 °C 8: 85 percent / NaTeH / ethanol / 0.5 h / 23 °C 9: 87 percent / t-BuNH3-BH3 / methanol / 21 h / 23 °C 10: 95 percent / TsOH / benzene / 1 h / 23 °C 11: 94 percent / MCPBA / CH2Cl2 / 0.5 h / -25 °C 12: 68 percent / CaCO3 / toluene / 70 h / Heating 13: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C 14: 89 percent / LiAlH4 / diethyl ether / 1 h / Heating 15: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating 16: 83 percent / 1.) OsO4, 2.) H2S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h 17: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C 18: 95 percent / TsOH / CHCl3; methanol / 0.67 h / 20 °C 19: 96 percent / pyridine / 2 h / 20 °C 20: 95 percent / TsOH / 0.25 h / 20 °C 21: 95 percent / LiAlH4 / diethyl ether / 0.17 h / 0 °C 22: 78 percent / SO3-pyridine, Et3N / dimethylsulfoxide / 16 h / 23 °C 23: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C 24: 79 percent / MnO2 / benzene / 3 h / 23 °C 25: 93 percent / diethyl ether / 0.25 h / -78 °C 26: 95 percent / 1.) 3 N HCl - THF, 23 deg C, 1 h, then 0.2 N KOH - THF - MeOH, 23 deg C, 20 min 27: 78 percent / 1.) PhSeCl, 2.) Ra-Ni(W-2) / 1.) CH2Cl2, 0 deg C, 38 h, 2.) EtOH, reflux, 5 min 28: 97 percent / n-Bu4NF / tetrahydrofuran / 5 h / 23 °C 29: 89 percent / n-Bu3P / tetrahydrofuran / 0.5 h / 23 °C 30: 84 percent / 30percent H2O2 / CH2Cl2 / 20 h / 18 °C 31: 96 percent / 1.) DDQ, 2.) K2CO3 / 1.) CH2Cl2 - H2O, 23 deg C, 48 h, 2.) MeOH, 23 deg C, 40 min 32: 77 percent / aq. HClO4; tetrahydrofuran / 60 h / 23 °C 33: 85 percent / pyridine / 9 h / 0 °C View Scheme

1: H2, quinoline / Lindlar catalyst / benzene / 2 h / 25 °C 2: DMAP / CH2Cl2 / 2 h / Heating 3: 35 percent / Pd(PPh3)4, Et3N / tetrahydrofuran / 5 h / Heating 4: 25 percent / toluene / 5 h / 220 - 230 °C / in sealed tube 5: 90 percent / OsO4, Me3NO, pyridine / 2-methyl-propan-2-ol; H2O / 18 h / Heating 6: 81 percent / SO3-pyridine, Et3N / 20 h / 20 °C 7: 85 percent / NaTeH / ethanol / 0.5 h / 23 °C 8: 87 percent / t-BuNH3-BH3 / methanol / 21 h / 23 °C 9: 95 percent / TsOH / benzene / 1 h / 23 °C 10: 94 percent / MCPBA / CH2Cl2 / 0.5 h / -25 °C 11: 68 percent / CaCO3 / toluene / 70 h / Heating 12: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C 13: 89 percent / LiAlH4 / diethyl ether / 1 h / Heating 14: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating 15: 83 percent / 1.) OsO4, 2.) H2S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h 16: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C 17: 95 percent / TsOH / CHCl3; methanol / 0.67 h / 20 °C 18: 96 percent / pyridine / 2 h / 20 °C 19: 95 percent / TsOH / 0.25 h / 20 °C 20: 95 percent / LiAlH4 / diethyl ether / 0.17 h / 0 °C 21: 78 percent / SO3-pyridine, Et3N / dimethylsulfoxide / 16 h / 23 °C 22: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C 23: 79 percent / MnO2 / benzene / 3 h / 23 °C 24: 93 percent / diethyl ether / 0.25 h / -78 °C 25: 95 percent / 1.) 3 N HCl - THF, 23 deg C, 1 h, then 0.2 N KOH - THF - MeOH, 23 deg C, 20 min 26: 78 percent / 1.) PhSeCl, 2.) Ra-Ni(W-2) / 1.) CH2Cl2, 0 deg C, 38 h, 2.) EtOH, reflux, 5 min 27: 97 percent / n-Bu4NF / tetrahydrofuran / 5 h / 23 °C 28: 89 percent / n-Bu3P / tetrahydrofuran / 0.5 h / 23 °C 29: 84 percent / 30percent H2O2 / CH2Cl2 / 20 h / 18 °C 30: 96 percent / 1.) DDQ, 2.) K2CO3 / 1.) CH2Cl2 - H2O, 23 deg C, 48 h, 2.) MeOH, 23 deg C, 40 min 31: 77 percent / aq. HClO4; tetrahydrofuran / 60 h / 23 °C 32: 85 percent / pyridine / 9 h / 0 °C View Scheme

1: DMAP / CH2Cl2 / 2 h / Heating 2: 35 percent / Pd(PPh3)4, Et3N / tetrahydrofuran / 5 h / Heating 3: 25 percent / toluene / 5 h / 220 - 230 °C / in sealed tube 4: 90 percent / OsO4, Me3NO, pyridine / 2-methyl-propan-2-ol; H2O / 18 h / Heating 5: 81 percent / SO3-pyridine, Et3N / 20 h / 20 °C 6: 85 percent / NaTeH / ethanol / 0.5 h / 23 °C 7: 87 percent / t-BuNH3-BH3 / methanol / 21 h / 23 °C 8: 95 percent / TsOH / benzene / 1 h / 23 °C 9: 94 percent / MCPBA / CH2Cl2 / 0.5 h / -25 °C 10: 68 percent / CaCO3 / toluene / 70 h / Heating 11: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C 12: 89 percent / LiAlH4 / diethyl ether / 1 h / Heating 13: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating 14: 83 percent / 1.) OsO4, 2.) H2S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h 15: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C 16: 95 percent / TsOH / CHCl3; methanol / 0.67 h / 20 °C 17: 96 percent / pyridine / 2 h / 20 °C 18: 95 percent / TsOH / 0.25 h / 20 °C 19: 95 percent / LiAlH4 / diethyl ether / 0.17 h / 0 °C 20: 78 percent / SO3-pyridine, Et3N / dimethylsulfoxide / 16 h / 23 °C 21: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C 22: 79 percent / MnO2 / benzene / 3 h / 23 °C 23: 93 percent / diethyl ether / 0.25 h / -78 °C 24: 95 percent / 1.) 3 N HCl - THF, 23 deg C, 1 h, then 0.2 N KOH - THF - MeOH, 23 deg C, 20 min 25: 78 percent / 1.) PhSeCl, 2.) Ra-Ni(W-2) / 1.) CH2Cl2, 0 deg C, 38 h, 2.) EtOH, reflux, 5 min 26: 97 percent / n-Bu4NF / tetrahydrofuran / 5 h / 23 °C 27: 89 percent / n-Bu3P / tetrahydrofuran / 0.5 h / 23 °C 28: 84 percent / 30percent H2O2 / CH2Cl2 / 20 h / 18 °C 29: 96 percent / 1.) DDQ, 2.) K2CO3 / 1.) CH2Cl2 - H2O, 23 deg C, 48 h, 2.) MeOH, 23 deg C, 40 min 30: 77 percent / aq. HClO4; tetrahydrofuran / 60 h / 23 °C 31: 85 percent / pyridine / 9 h / 0 °C View Scheme

1: 35 percent / Pd(PPh3)4, Et3N / tetrahydrofuran / 5 h / Heating 2: 25 percent / toluene / 5 h / 220 - 230 °C / in sealed tube 3: 90 percent / OsO4, Me3NO, pyridine / 2-methyl-propan-2-ol; H2O / 18 h / Heating 4: 81 percent / SO3-pyridine, Et3N / 20 h / 20 °C 5: 85 percent / NaTeH / ethanol / 0.5 h / 23 °C 6: 87 percent / t-BuNH3-BH3 / methanol / 21 h / 23 °C 7: 95 percent / TsOH / benzene / 1 h / 23 °C 8: 94 percent / MCPBA / CH2Cl2 / 0.5 h / -25 °C 9: 68 percent / CaCO3 / toluene / 70 h / Heating 10: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C 11: 89 percent / LiAlH4 / diethyl ether / 1 h / Heating 12: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating 13: 83 percent / 1.) OsO4, 2.) H2S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h 14: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C 15: 95 percent / TsOH / CHCl3; methanol / 0.67 h / 20 °C 16: 96 percent / pyridine / 2 h / 20 °C 17: 95 percent / TsOH / 0.25 h / 20 °C 18: 95 percent / LiAlH4 / diethyl ether / 0.17 h / 0 °C 19: 78 percent / SO3-pyridine, Et3N / dimethylsulfoxide / 16 h / 23 °C 20: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C 21: 79 percent / MnO2 / benzene / 3 h / 23 °C 22: 93 percent / diethyl ether / 0.25 h / -78 °C 23: 95 percent / 1.) 3 N HCl - THF, 23 deg C, 1 h, then 0.2 N KOH - THF - MeOH, 23 deg C, 20 min 24: 78 percent / 1.) PhSeCl, 2.) Ra-Ni(W-2) / 1.) CH2Cl2, 0 deg C, 38 h, 2.) EtOH, reflux, 5 min 25: 97 percent / n-Bu4NF / tetrahydrofuran / 5 h / 23 °C 26: 89 percent / n-Bu3P / tetrahydrofuran / 0.5 h / 23 °C 27: 84 percent / 30percent H2O2 / CH2Cl2 / 20 h / 18 °C 28: 96 percent / 1.) DDQ, 2.) K2CO3 / 1.) CH2Cl2 - H2O, 23 deg C, 48 h, 2.) MeOH, 23 deg C, 40 min 29: 77 percent / aq. HClO4; tetrahydrofuran / 60 h / 23 °C 30: 85 percent / pyridine / 9 h / 0 °C View Scheme

1: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C 2: 89 percent / LiAlH4 / diethyl ether / 1 h / Heating 3: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating 4: 83 percent / 1.) OsO4, 2.) H2S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h 5: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C 6: 95 percent / TsOH / CHCl3; methanol / 0.67 h / 20 °C 7: 96 percent / pyridine / 2 h / 20 °C 8: 95 percent / TsOH / 0.25 h / 20 °C 9: 95 percent / LiAlH4 / diethyl ether / 0.17 h / 0 °C 10: 78 percent / SO3-pyridine, Et3N / dimethylsulfoxide / 16 h / 23 °C 11: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C 12: 79 percent / MnO2 / benzene / 3 h / 23 °C 13: 93 percent / diethyl ether / 0.25 h / -78 °C 14: 95 percent / 1.) 3 N HCl - THF, 23 deg C, 1 h, then 0.2 N KOH - THF - MeOH, 23 deg C, 20 min 15: 78 percent / 1.) PhSeCl, 2.) Ra-Ni(W-2) / 1.) CH2Cl2, 0 deg C, 38 h, 2.) EtOH, reflux, 5 min 16: 97 percent / n-Bu4NF / tetrahydrofuran / 5 h / 23 °C 17: 89 percent / n-Bu3P / tetrahydrofuran / 0.5 h / 23 °C 18: 84 percent / 30percent H2O2 / CH2Cl2 / 20 h / 18 °C 19: 96 percent / 1.) DDQ, 2.) K2CO3 / 1.) CH2Cl2 - H2O, 23 deg C, 48 h, 2.) MeOH, 23 deg C, 40 min 20: 77 percent / aq. HClO4; tetrahydrofuran / 60 h / 23 °C 21: 85 percent / pyridine / 9 h / 0 °C View Scheme

1: 89 percent / LiAlH4 / diethyl ether / 1 h / Heating 2: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating 3: 83 percent / 1.) OsO4, 2.) H2S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h 4: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C 5: 95 percent / TsOH / CHCl3; methanol / 0.67 h / 20 °C 6: 96 percent / pyridine / 2 h / 20 °C 7: 95 percent / TsOH / 0.25 h / 20 °C 8: 95 percent / LiAlH4 / diethyl ether / 0.17 h / 0 °C 9: 78 percent / SO3-pyridine, Et3N / dimethylsulfoxide / 16 h / 23 °C 10: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C 11: 79 percent / MnO2 / benzene / 3 h / 23 °C 12: 93 percent / diethyl ether / 0.25 h / -78 °C 13: 95 percent / 1.) 3 N HCl - THF, 23 deg C, 1 h, then 0.2 N KOH - THF - MeOH, 23 deg C, 20 min 14: 78 percent / 1.) PhSeCl, 2.) Ra-Ni(W-2) / 1.) CH2Cl2, 0 deg C, 38 h, 2.) EtOH, reflux, 5 min 15: 97 percent / n-Bu4NF / tetrahydrofuran / 5 h / 23 °C 16: 89 percent / n-Bu3P / tetrahydrofuran / 0.5 h / 23 °C 17: 84 percent / 30percent H2O2 / CH2Cl2 / 20 h / 18 °C 18: 96 percent / 1.) DDQ, 2.) K2CO3 / 1.) CH2Cl2 - H2O, 23 deg C, 48 h, 2.) MeOH, 23 deg C, 40 min 19: 77 percent / aq. HClO4; tetrahydrofuran / 60 h / 23 °C 20: 85 percent / pyridine / 9 h / 0 °C View Scheme

1: 90 percent / OsO4, Me3NO, pyridine / 2-methyl-propan-2-ol; H2O / 18 h / Heating 2: 81 percent / SO3-pyridine, Et3N / 20 h / 20 °C 3: 85 percent / NaTeH / ethanol / 0.5 h / 23 °C 4: 87 percent / t-BuNH3-BH3 / methanol / 21 h / 23 °C 5: 95 percent / TsOH / benzene / 1 h / 23 °C 6: 94 percent / MCPBA / CH2Cl2 / 0.5 h / -25 °C 7: 68 percent / CaCO3 / toluene / 70 h / Heating 8: 92 percent / LiOMe / tetrahydrofuran / 72 h / 23 °C 9: 89 percent / LiAlH4 / diethyl ether / 1 h / Heating 10: 90 percent / DMAP / 1,2-dichloro-ethane / 6 h / Heating 11: 83 percent / 1.) OsO4, 2.) H2S / 1.) pyridine, 20 deg C, 30 h, 2.) chloroform - dioxane, 23 deg C, 0.5 h 12: 91 percent / NaH / hexamethylphosphoric acid triamide; tetrahydrofuran / 3 h / 23 °C 13: 95 percent / TsOH / CHCl3; methanol / 0.67 h / 20 °C 14: 96 percent / pyridine / 2 h / 20 °C 15: 95 percent / TsOH / 0.25 h / 20 °C 16: 95 percent / LiAlH4 / diethyl ether / 0.17 h / 0 °C 17: 78 percent / SO3-pyridine, Et3N / dimethylsulfoxide / 16 h / 23 °C 18: 80 percent / tetrahydrofuran / 2 h / -78 - 20 °C 19: 79 percent / MnO2 / benzene / 3 h / 23 °C 20: 93 percent / diethyl ether / 0.25 h / -78 °C 21: 95 percent / 1.) 3 N HCl - THF, 23 deg C, 1 h, then 0.2 N KOH - THF - MeOH, 23 deg C, 20 min 22: 78 percent / 1.) PhSeCl, 2.) Ra-Ni(W-2) / 1.) CH2Cl2, 0 deg C, 38 h, 2.) EtOH, reflux, 5 min 23: 97 percent / n-Bu4NF / tetrahydrofuran / 5 h / 23 °C 24: 89 percent / n-Bu3P / tetrahydrofuran / 0.5 h / 23 °C 25: 84 percent / 30percent H2O2 / CH2Cl2 / 20 h / 18 °C 26: 96 percent / 1.) DDQ, 2.) K2CO3 / 1.) CH2Cl2 - H2O, 23 deg C, 48 h, 2.) MeOH, 23 deg C, 40 min 27: 77 percent / aq. HClO4; tetrahydrofuran / 60 h / 23 °C 28: 85 percent / pyridine / 9 h / 0 °C View Scheme