3-乙炔基哌啶-1-甲酸叔丁酯合成路线 （共 4 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h;
参考文献
ADDEX PHARMACEUTICALS SA
Patent: WO2005/44797 A1, 2005 ;
Location in patent: Page/Page column 54 ;
WO 2005/044797 A1
反应条件
potassium carbonate in methanol T=20°C; 3 h;
参考文献
Bourrain, Sylvie; Hunt, Peter Alan; Huscroft, Ian Thomas; Kulagowski, Janusz Jozef; London, Clare; Naylor, Elizabeth Mary; Raubo, Piotr Antoni; Seward, Eileen Mary
Patent: US2004/229864 A1, 2004 ;
Location in patent: Page/Page column 11 ;
US 20040229864 A1
反应条件
potassium carbonate in methanol 2.16667 h; Cooling with ice;
参考文献
Astar Biotech LLC; YU, Chunrong; Huang, Haihong; Zhang, Dongfeng; Li, Peng
Patent: US2014/31354 A1, 2014 ;
Location in patent: Paragraph 0296; 0421; 0422 ;
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 16 h;
参考文献
UCB PHARMA S.A.
Patent: WO2007/141504 A1, 2007 ;
Location in patent: Page/Page column 59 ;
WO 2007/141504 A1
