1-[(1,1-二甲基乙氧基)羰基]-3-吡咯烷羧酸乙酯合成路线 (共 1 条)
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 0.5 h;
2: 3-Oxo-pyrrolidine-1-carboxylic acid tert-butyl ester in N,N-dimethyl-formamide
T=0 - 20°C; 1 h;
3: With palladium 10 on activated carbon; hydrogen in ethanol; water
T=20°C; 2 h;
参考文献
Watanabe, Kazushi; Kakefuda, Akio; Yasuda, Minoru; Enjo, Kentaro; Kikuchi, Aya; Furutani, Takashi; Naritomi, Yoichi; Otsuka, Yukio; Okada, Minoru; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5261 - 5270