2-呋喃-2-咪唑并[1,2-a]嘧啶合成路线 （共 5 条）
反应条件
1: 2-acetyl-furan With (hydroxy(tosyloxy)iodo)benzene; 1-butylpyridinium tetrafluoroborate
Heating;
2: 2-amino-pyrimidine With sodium carbonate; 1-butylpyridinium tetrafluoroborate
T=20°C;
参考文献
Xie, Yuan-Yuan
Synthetic Communications, 2005 , vol. 35, # 13 p. 1741 - 1746
反应条件
sodium carbonate in poly(ethylene glycol-400)
T=20°C; 0.5 h;
参考文献
Cheng, Hui-Ting; Hou, Rei-Sheu; Wang, Huey-Min; Kang, Iou-Jiun; Lin, Pei-Ying; Chena, Ling-Ching
Journal of the Chinese Chemical Society, 2009 , vol. 56, # 3 p. 632 - 635
反应条件
in acetonitrile
1.) room temp., 1 h, 2.) reflux, 24 h;
参考文献
Louiseau; Payard; Grassy; Dornelles Pinto; Advenier; Gnassounou; Adam
European Journal of Medicinal Chemistry, 1987 , vol. 22, # 5 p. 457 - 462
反应条件
1: 89 percent / diethyl ether / 120 h / 20 °C
2: 58 percent / aq. NaHCO3 / 3 h / Heating
View Scheme
参考文献
Saldabol; Popelis; Lando; Slavinska
Chemistry of Heterocyclic Compounds, 2006 , vol. 42, # 4 p. 495 - 499
反应条件
bromine in chloroform
参考文献
Saldabol,N.O.; Lando,O.E.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1978 , vol. 14, p. 211 - 215
Khimiya Geterotsiklicheskikh Soedinenii, 1978 , vol. 14, p. 258 - 262
