(4-硝基-1H-吡唑-1-基)乙酸合成路线 （共 3 条）
反应条件
1: 4-nitropyrazole With potassium hydroxide in water; acetone
T=20°C; 0.5 h;
2: monobromoacetic acid in water; acetone
T=20°C;
参考文献
CELLZOME LIMITED; HARRISON, Richard John; RAMSDEN, Nigel; MAJOR, Jeremy; MOREL, Adeline; CONVERY, Laura; SUNOSE, Mihiro; LYNCH, Rosemary; ADREGO, Rita; JONES, Alison
Patent: WO2013/174895 A1, 2013 ;
Location in patent: Page/Page column 70 ;
反应条件
sulfuric acid; nitric acid
T=0 - 20°C; 18 h;
参考文献
CHROMA THERAPEUTICS LTD
Patent: WO2006/117552 A1, 2006 ;
Location in patent: Page/Page column 50-52 ;
WO 2006/117552 A1
反应条件
potassium hydroxide in methanol
参考文献
Kanishchev, M. I.; Kral, V.; Arnold, Z.; Semenov, V. V.; Shevelev, S. A.; Fainzil'berg, A. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, # 10 p. 2191
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 10 p. 2392
