7-氨基-3,4-二氢异喹啉-1(2H)-酮合成路线 （共 19 条）
反应条件
1: 4.3 percent Chromat. / 1) NaNO2, 3 N HCl, 2) KI / 1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h 2: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
hydrogenchloride; potassium iodide; sodium nitrite in water
参考文献
NOVARTIS AG; BOCK, Mark G.; GAUL, Christoph; GUMMADI, Venkateshwar Rao; MOEBITZ, Henrik; SENGUPTA, Saumitra
Patent: WO2012/35078 A1, 2012 ;
Location in patent: Page/Page column 91 ;
WO 2012/035078 A1
反应条件
1: With hydrogenchloride; sodium nitrite in water
T=0°C; 0.25 h;
2: With copper(l) iodide; potassium iodide in dichloromethane; water
T=20°C;
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
Location in patent: Paragraph 0579 ;
反应条件
hydrogenchloride; potassium iodide; sodium nitrite
1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
1: With hydrogenchloride; sodium nitrite in water
T=5°C; 0.5 h;
2: With hydrogenchloride; tin(ll) chloride in water
T=0°C; 2 h;
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.
Patent: WO2013/36232 A2, 2013 ;
Location in patent: Paragraph 00353 ;
反应条件
1: 1) NaNO2, 3 N HCl, 2) KI / 1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h
2: 60 percent / conc. HCl / 30 h / 150 °C / 31028.9 Torr
View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
1: 1) NaNO2, 3 N HCl, 2) KI / 1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h
2: 60 percent / conc. HCl / 30 h / 150 °C / 31028.9 Torr
3: 84 percent / NaOAc / H2O; acetic acid / 1 h / 50 °C
View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
1: 4.3 percent Chromat. / 1) NaNO2, 3 N HCl, 2) KI / 1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h
2: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C
3: 64 percent / conc. HCl / 24 h / 150 °C
View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
反应条件
1: 4.3 percent Chromat. / 1) NaNO2, 3 N HCl, 2) KI / 1) H2O, 0 degC, 1.5 h, 2) warm to room temp., 4 h
2: 95 percent / fuming HNO3, conc. H2SO4 / 0.5 h / 0 °C
3: 64 percent / conc. HCl / 24 h / 150 °C
4: H2O; acetic acid / 2 h / 50 °C
View Scheme
参考文献
Girard; Atkinson; Belanger; et al.
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234
