3-羟基-6-甲基吡啶-2-羧醛合成路线 （共 6 条）
反应条件
manganese(IV) oxide in acetone T=20°C; 12 h;
参考文献
WO2004/37808 A1, ;
Page 22-23 ;
反应条件
sodium hydroxide in ethanol; water
参考文献
US5180831 A1, ;
US 5180831 A
反应条件
in acetonitrile 22 h; Heating;
参考文献
Acta Chemica Scandinavica, , vol. 53, # 4 p. 258 - 262
反应条件
perchloric acid; sodium dichromate; sodium perchlorate T=24.85°C; Kinetics; Further Variations:ReagentsTemperatures;
参考文献
Polish Journal of Chemistry, , vol. 77, # 3 p. 355 - 364
反应条件
1: 85 percent / toluene / 0.5 h / 50 °C 2: 53 percent / Ph3P, diethyl azodicarboxylate / tetrahydrofuran / 1.25 h / 0 - 20 °C 3: MCPBA / CH2Cl2 / 18 h / Ambient temperature 4: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature 5: SOCl2 / toluene / 1 h 6: 87 percent / DBU / acetonitrile / 1 h / 50 °C 7: 60 percent / aq. LiOH / methanol; tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Daines, Robert A.; Chambers, Pamela A.; Foley, James J.; Griswold, Don E.; Kingsbury, William D.; Martin, Lenox D.; Schmidt, Dulcie B.; Sham, Kelvin K. C.; Sarau, Henry M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 19 p. 3837 - 3841
反应条件
sodium cyanide; manganese(IV) oxide; acetic acid
T=20°C;
参考文献
CHONG KUN DANG PHARMACEUTICAL CORP.
Patent: WO2004/37808 A1, 2004 ;
Location in patent: Page 22-23 ;
