1.1: 89.4 percent / NaHCO3; I2 / acetone; H2O / 0.25 h / 0 °C 2.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: tetrahydrofuran; hexane / -78 - 20 °C 3.1: 2.25 g / TiCl4 / CH2Cl2 / 1 h / -78 °C 4.1: 97 percent / DBU / methanol / 1 h / 0 °C 5.1: BuLi / tetrahydrofuran; hexane / 1 h / -78 °C 5.2: MeCuCNLi / tetrahydrofuran; hexane; diethyl ether / 1 h / -78 °C 5.3: 92.6 percent / tetrahydrofuran; hexane; diethyl ether / 1 h / -78 °C 6.1: 131 mg / (S)-2-methyl-CBS-oxazaborolidine; BH3*Me2S / tetrahydrofuran; toluene / 0.25 h / 0 °C 7.1: 96.4 percent / diethyl ether / 1 h / 0 °C 8.1: 72 percent / Li-naphthalene / tetrahydrofuran / -25 °C 9.1: MnO2 / CH2Cl2 / 3 h / Heating 10.1: 33.6 mg / NaH2PO4; 2-methyl-2-butene; NaClO2 / 2-methyl-propan-2-ol; H2O / 20 °C 11.1: NEt3; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 6 h 11.2: 81 percent / DMAP / tetrahydrofuran; toluene / Heating 12.1: 91 percent / aq. HCl / tetrahydrofuran; H2O / 48 h / 20 °C View Scheme