1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷合成路线 （共 6 条）
反应条件
borane in tetrahydrofuran
T=100°C; 1 h;
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
反应条件
hydrogenchloride; sodium hydroxide in tetrahydrofuran
参考文献
American Cyanamid Company
Patent: US4131611 A1, 1978 ;
反应条件
1: 80 percent / NBS, 48percent aq. HBr / CCl4 / Heating
2: 29 percent / NaOEt / diethyl ether / 24 h / Ambient temperature
3: 40 percent / KOH / ethanol; H2O / 6 h / Heating
4: 84 percent / urea / xylene / Heating
5: 65 percent / BH3 / tetrahydrofuran / 1 h / 100 °C
View Scheme
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
反应条件
1: 29 percent / NaOEt / diethyl ether / 24 h / Ambient temperature
2: 40 percent / KOH / ethanol; H2O / 6 h / Heating
3: 84 percent / urea / xylene / Heating
4: 65 percent / BH3 / tetrahydrofuran / 1 h / 100 °C
View Scheme
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
反应条件
1: 84 percent / urea / xylene / Heating
2: 65 percent / BH3 / tetrahydrofuran / 1 h / 100 °C
View Scheme
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
反应条件
1: 40 percent / KOH / ethanol; H2O / 6 h / Heating
2: 84 percent / urea / xylene / Heating
3: 65 percent / BH3 / tetrahydrofuran / 1 h / 100 °C
View Scheme
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
