4-(3-三氟甲基苯基)哌啶盐酸盐合成路线 （共 6 条）
反应条件
palladium 10 on activated carbon; hydrogen in ethanol 60 h;
参考文献
Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564
反应条件
hydrogenchloride; hydrogen; palladium/carbon catalyst in ethanol
反应条件
1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux 1.2: 3 h / 20 °C / Inert atmosphere; Cooling with ice 2.1: methanesulfonic acid / toluene / 4 h / Reflux 3.1: hydrogenchloride / diethyl ether; ethyl acetate 4.1: palladium 10 on activated carbon; hydrogen / ethanol / 60 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 7 p. 2560 - 2564
反应条件
1: hydrogenchloride / diethyl ether; ethyl acetate 2: palladium 10 on activated carbon; hydrogen / ethanol / 60 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 7 p. 2560 - 2564
反应条件
1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux 1.2: 3 h / 20 °C / Inert atmosphere; Cooling with ice 2.1: methanesulfonic acid / toluene / 4 h / Reflux 3.1: hydrogenchloride / diethyl ether; ethyl acetate 4.1: palladium 10 on activated carbon; hydrogen / ethanol / 60 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 7 p. 2560 - 2564
反应条件
1: methanesulfonic acid / toluene / 4 h / Reflux 2: hydrogenchloride / diethyl ether; ethyl acetate 3: palladium 10 on activated carbon; hydrogen / ethanol / 60 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 7 p. 2560 - 2564
