AD-mix β; methanesulfonamide in water; tert-butyl alcohol T=0°C; Sharpless Dihydroxylation; 16 h; enantioselective reaction;

1: With sodium hypochlorite; 4-phenylpyridine-N-oxide; phosphate buffer; (S,S)-Jacobsen’s catalyst in dichloromethane T=-10 - 0°C; pH=11; 18 h; 2: With trifluoroacetic acid in diethyl ether; water T=0°C; Title compound not separated from byproducts;

1: With sodium hypochlorite; 4-phenylpyridine-N-oxide; phosphate buffer; (S,S)-Jacobsen’s catalyst in dichloromethane T=-10 - 0°C; pH=11; 18 h; 2: With trifluoroacetic acid in diethyl ether; water T=0°C; Title compound not separated from byproducts;