4-(3-吡啶基)-2-氨基嘧啶合成路线 （共 16 条）
反应条件
sodium hydroxide in butan-1-ol T=120°C; 2 h;
参考文献
SYNTECH SOLUTION LLC; CHEN, Yongsheng
Patent: WO2010/96395 A1, 2010 ;
Location in patent: Page/Page column 36 ;
WO 2010/096395 A1
反应条件
1-(2,6-diisopropylphenyl)-3-(2-oxo-2-(2,4,6-tri-tert-butylphenylamino)ethyl)-1H-imidazol-3-ium bromide; palladium diacetate; sodium hydroxide in water; dimethyl sulfoxide T=100°C; Suzuki Coupling; 10 h;
参考文献
Heo, Yumi; Hyun, Dajung; Kumar, Manian Rajesh; Jung, Hyun Min; Lee, Sunwoo
Tetrahedron Letters, 2012 , vol. 53, # 49 p. 6657 - 6661
反应条件
1: 1-methylguanidine hydrochloride With ethanol; sodium ethanolate T=20°C; 1 h; 2: 3-(dimethylamino)-1-(3-pyridinyl)prop-2-en-1-one in ethanol 6 h; Reflux;
参考文献
El-Deeb, Ibrahim Mustafa; Lee, So Ha
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 11 p. 3860 - 3874
反应条件
1-methylguanidine hydrochloride; sodium hydroxide in isopropyl alcohol 12 h; Reflux;
参考文献
Koroleva; Ignatovich, Zh.V.; Ignatovich; Gusak
Russian Journal of Organic Chemistry, 2011 , vol. 47, # 8 p. 1222 - 1226
反应条件
sodium hydroxide in butan-1-ol 12 h; Inert atmosphereSchlenk techniqueReflux;
参考文献
Liu, Yi-Feng; Wang, Cui-Ling; Bai, Ya-Jun; Han, Ning; Jiao, Jun-Ping; Qi, Xiao-Li
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 490 - 495
反应条件
1: With (1H)-pyrimidine; hydrazine hydrate in methanol T=50 - 60°C; 0.25 h; 2: in water
参考文献
Koroleva; Ignatovich, Zh.V.; Ignatovich; Gusak
Russian Journal of Organic Chemistry, 2011 , vol. 47, # 8 p. 1222 - 1226
反应条件
1: 2-nitro-aniline With nitric acid in ethanol T=0°C; 2: Carbamonitrile in water pH=Ca. 3; Reflux; 3: 3-(dimethylamino)-1-(3-pyridinyl)prop-2-en-1-one in isopropyl alcohol Reflux;
参考文献
Koroleva; Ignatovich, Zh.V.; Ignatovich; Gusak
Russian Journal of Organic Chemistry, 2011 , vol. 47, # 8 p. 1222 - 1226
反应条件
sodium hydroxide in butan-1-ol T=120°C; 4 h; Reflux;
参考文献
Arioli, Federica; Borrelli, Stella; Colombo, Francesco; Falchi, Federico; Filippi, Irene; Crespan, Emmanuele; Naldini, Antonella; Scalia, Giusy; Silvani, Alessandra; Maga, Giovanni; Carraro, Fabio; Botta, Maurizio; Passarella, Daniele
ChemMedChem, 2011 , vol. 6, # 11 p. 2009 - 2018
反应条件
1: 2,2-dimethoxy-propane / anhydrous xylene / 20 h / 140 °C / Reflux 2: sodium hydroxide / butan-1-ol / 4 h / 120 °C / Reflux View Scheme
参考文献
ChemMedChem, , vol. 6, # 11 p. 2009 - 2018
反应条件
1: potassium tert-butylate / dimethyl sulfoxide / 12 h / 120 °C 2: tin(ll) chloride; hydrogenchloride / methanol / 10 h / 50 °C 3: triethylamine / tetrahydrofuran / 7 h / 0 - 20 °C View Scheme
参考文献
Liu, Yi-Feng; Wang, Cui-Ling; Bai, Ya-Jun; Han, Ning; Jiao, Jun-Ping; Qi, Xiao-Li
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 490 - 495
