4-(3-吡啶基)-2-氨基嘧啶合成路线 （共 16 条）
反应条件
copper(l) iodide; potassium carbonate in 1,4-dioxane T=20 - 120°C; Sealed tubeInert atmosphere;
参考文献
Kalesh, Karunakaran A.; Liu, Kai; Yao, Shao Q.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 24 p. 5129 - 5136
反应条件
C43H63ClNO2PPd; caesium carbonate in 1,4-dioxane T=120°C; 1.5 h; Inert atmosphere;
参考文献
Ueda, Satoshi; Su, Mingjuan; Buchwald, Stephen L.
Journal of the American Chemical Society, 2012 , vol. 134, # 1 p. 700 - 706
反应条件
caesium carbonate; tris(dibenzylideneacetone)dipalladium (0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane; tert-butyl alcohol T=100°C; 7 h;
参考文献
Synthesis, , # 14 p. 2121 - 2124
反应条件
1: C43H63ClNO2PPd; caesium carbonate / 1,4-dioxane / 1.5 h / 120 °C / Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 1 p. 700 - 706
反应条件
1: 4-(pyridin-3-yl)pyrimidin-2-ylamine With C43H62NO2PPd; sodium t-butanolate in 1,4-dioxane; tert-butyl alcohol 0.166667 h; Sonication; 2: N-(3-bromo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide With 1,8-diazabicyclo[5.4.0]undec-7-ene in 1,4-dioxane; tert-butyl alcohol T=150°C; 0.5 h;
参考文献
Hopkin, Mark D.; Baxendale, Ian R.; Ley, Steven V.
Chemical Communications, 2010 , vol. 46, # 14 p. 2450 - 2452
反应条件
1: potassium tert-butylate / dimethyl sulfoxide / 12 h / 120 °C 2: tin(ll) chloride; hydrogenchloride / methanol / 10 h / 50 °C 3: triethylamine / tetrahydrofuran / 7 h / 0 - 20 °C 4: calcium carbonate / N,N-dimethyl-formamide View Scheme
参考文献
Liu, Yi-Feng; Wang, Cui-Ling; Bai, Ya-Jun; Han, Ning; Jiao, Jun-Ping; Qi, Xiao-Li
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 490 - 495
