3-甲基-6-(3-[三氟甲基]苯基)-1,2,4-噻唑并-(4,3-b)吡嗪合成路线 （共 5 条）
参考文献
American Cyanamid Company
Patent: US4112095 A1, 1978 ;
反应条件
1: 1.5135 g / p-toluenesulfonic acid / toluene / 44 h / Heating
2: 0.72 percent / tetrahydrofuran / 16 h / 23 °C
3: acetic acid / 19 h / Heating
View Scheme
参考文献
Lieberman, Daniel F.; Albright, J. Donald
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 827 - 830
反应条件
in butan-1-ol
48 h; Heating;
参考文献
Albright, J. D.; Moran, D. B.; Wright, W. B.; Collins, J. B.; Beer, B.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 592 - 600
反应条件
in acetic acid
19 h; Heating; Yield given;
参考文献
Lieberman, Daniel F.; Albright, J. Donald
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 827 - 830
反应条件
1: 0.72 percent / tetrahydrofuran / 16 h / 23 °C
2: acetic acid / 19 h / Heating
View Scheme
参考文献
Lieberman, Daniel F.; Albright, J. Donald
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 827 - 830
