2-甲基-3-硝基三氟甲苯合成路线 （共 6 条）
反应条件
hydrogen in methanol
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 16 h; Irradiationheating;
参考文献
Apfel; Banner; Bur; Dietz; Hubschwerlen; Locher; Marlin; Masciadri; Pirson; Stalder
Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 1847 - 1852
反应条件
1: N,N-dimethyl-formamide / 110 °C 2: acetic acid; iron / 16 h / |Reflux View Scheme
参考文献
SANOFI; Brollo, Maurice; Carry, Jean-Christophe; Certal, Victor; Didier, Eric; Doerflinger, Gilles; EL Ahmad, Youssef; Filoche-Romme, Bruno; Halley, Frank; Karlsson, Karl Andreas; Schio, Laurent; Thompson, Fabienne
Patent: US2013/274253 A1, 2013 ;
反应条件
1: NaH / dimethylformamide / Ambient temperature 2: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h 3: H2 / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr 4: MeONa / methanol / 3 h / Heating 5: LiBr / dimethylformamide / 4 h / Heating 6: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, toluene, heating, 2 h View Scheme
参考文献
Kimball; Floyd; Das; Hunt; Krapcho; Rovnyak; Duff; Lee; Moquin; Turk; Hedberg; Moreland; Brittain; McMullen; Normandin; Cucinotta
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 780 - 793
反应条件
1: N-iodosuccinimide / H2SO4 / 21 h / 5 - 20 °C 2: MeONa / methanol / 20 h / 20 °C 3: 37.14 g / aq. HClO4; AcOH; aq. H2O2 / 4 h / 50 °C 4: HCl / 4.5 h / Heating 5: 21.59 g / aq. TiCl3 / methanol / 20 h / 20 °C 6: 35.2 g / pyridinium bromide perbromide / 2-methyl-propan-2-ol / 4 h / 20 °C 7: 16.26 percent / H2O / methanol / 24 h / Heating View Scheme
参考文献
Ewan Hume; Tokunaga, Teruhisa; Nagata, Ryu
Tetrahedron, 2002 , vol. 58, # 18 p. 3605 - 3611
