1-(4,5-二甲基-2-噻吩)乙酮合成路线 （共 6 条）
反应条件
tin(IV) chloride in benzene
T=-5 - 20°C; Friedel-Crafts acylation; 2 h;
参考文献
Tranberg, C. Elisabet; Zickgraf, Andrea; Giunta, Brian N.; Luetjens, Henning; Figler, Heidi; Murphree, Lauren J.; Falke, Ruediger; Fleischer, Holger; Linden, Joel; Scammells, Peter J.; Olsson, Ray A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 382 - 389
反应条件
hydrogenchloride in water; benzene
参考文献
Linden, Joel M.; Ollson, Ray A.; Scammells, Peter J.
Patent: US2003/78248 A1, 2003 ;
反应条件
1.1: hydrazine hydrate; ethylene glycol / 130 - 160 °C
1.2: 77 percent / KOH / 0.25 h / 90 - 100 °C
2.1: 79 percent / tin(IV) chloride / benzene / 2 h / -5 - 20 °C
View Scheme
参考文献
Tranberg, C. Elisabet; Zickgraf, Andrea; Giunta, Brian N.; Luetjens, Henning; Figler, Heidi; Murphree, Lauren J.; Falke, Ruediger; Fleischer, Holger; Linden, Joel; Scammells, Peter J.; Olsson, Ray A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 382 - 389
反应条件
2: benzene; water containing phosphoric acid
View Scheme
参考文献
Hartough
Journal of the American Chemical Society, 1951 , vol. 73, p. 4033
反应条件
phosphoric acid; benzene
参考文献
Hartough
Journal of the American Chemical Society, 1951 , vol. 73, p. 4033
反应条件
1: 85 percent / hydroxylamine hydrochloride; barium carbonate / ethanol / 8 h / Heating
2: 32 percent / PCl5 / diethyl ether / 0.75 h / 0 - 20 °C
3: 82 percent / tin(IV) chloride / 1,2-dichloro-ethane / 10.5 h / Heating
4: 98 percent / aq. KOH / methanol / 0.75 h / Heating
View Scheme
参考文献
Tranberg, C. Elisabet; Zickgraf, Andrea; Giunta, Brian N.; Luetjens, Henning; Figler, Heidi; Murphree, Lauren J.; Falke, Ruediger; Fleischer, Holger; Linden, Joel; Scammells, Peter J.; Olsson, Ray A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 382 - 389
