(2E,4E,6E,8E)-9-(3-羟基-2,6,6-三甲基-1-环己烯基)-3,7-二甲基-壬-2,4,6,8-四烯酸合成路线 （共 7 条）
反应条件
potassium hydroxide in methanol; water
1 h; Heating; Yield given;
参考文献
Rosenberger
Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1698 - 1701
反应条件
1: 60 percent / sodium methoxide / CH2Cl2; methanol / 1) -20 - -24 deg C, 8 min; 2) room temperature, 2 h
2: 100 percent / sodium borohydride / ethanol / 20 h
3: 1.) potassium hydroxide, 2.) glacial acetic acid / 1) ethanol, waterreflux, 30 min; 2) CH2Cl2, pH 5.5, 30 min
View Scheme
参考文献
Aig, Edward; Focella, Antonino; Parrish, David R.; Rosenberger, Michael; Scott, John W.; Zenchoff, Gladys B.
Synthetic Communications, 1987 , vol. 17, # 4 p. 419 - 430
反应条件
1: 100 percent / sodium borohydride / ethanol / 20 h
2: 1.) potassium hydroxide, 2.) glacial acetic acid / 1) ethanol, waterreflux, 30 min; 2) CH2Cl2, pH 5.5, 30 min
View Scheme
参考文献
Aig, Edward; Focella, Antonino; Parrish, David R.; Rosenberger, Michael; Scott, John W.; Zenchoff, Gladys B.
Synthetic Communications, 1987 , vol. 17, # 4 p. 419 - 430
反应条件
N-acetylglucosaminyltransferase I-negative HEK-293S cells transfected with cytochrome P450 enzymes CYP26A1 (HEK-CYP26A1 cells)
4 h; Enzymatic reaction; Product distribution / selectivity;
参考文献
UNIVERSITY OF WASHINGTON
Patent: US2008/249042 A1, 2008 ;
Location in patent: Page/Page column 2; 27; 29; 31; Sheet 14/24; 24/24 ;
反应条件
sodium tetrahydroborate in methanol
参考文献
Arnold, Samuel L. M.; Amory, John K.; Walsh, Thomas J.; Isoherranen, Nina
Journal of Lipid Research, 2012 , vol. 53, # 3 p. 587 - 598
反应条件
potassium hydroxide; acetic acid
1) ethanol, waterreflux, 30 min; 2) CH2Cl2, pH 5.5, 30 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Aig, Edward; Focella, Antonino; Parrish, David R.; Rosenberger, Michael; Scott, John W.; Zenchoff, Gladys B.
Synthetic Communications, 1987 , vol. 17, # 4 p. 419 - 430
反应条件
cytochrome P450 3A4 enzyme; water; NADPH in aq. phosphate buffer
T=37°C; pH=7.4; Enzymatic reaction; Kinetics; Reagent/catalyst;
参考文献
Shimshoni, Jakob A.; Roberts, Arthur G.; Scian, Michele; Topletz, Ariel R.; Blankert, Sean A.; Halpert, James R.; Nelson, Wendel L.; Isoherranen, Nina
Journal of Biological Chemistry, 2012 , vol. 287, # 50 p. 42223 - 42232
