N-Boc-L-苯丙氨醇合成路线 （共 89 条）
反应条件
1: LAH / tetrahydrofuran / 6 h / Heating 2: CHCl3 / 4 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 8 p. 1487 - 1492
反应条件
sodium tetrahydroborate in ethylene glycol dimethyl ether; water T=-15°C; 0.00833333 h; Yield given;
参考文献
Tetrahedron Letters, , vol. 32, # 7 p. 923 - 926
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water Ambient temperature;
参考文献
Rubini, E.; Gilon, C.; Selinger, Z.; Chorev, M.
Tetrahedron, 1986 , vol. 42, # 21 p. 6039 - 6045
反应条件
1: 85 percent / imidazole / dimethylformamide / 24 h / Ambient temperature 2: 83 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 5 h / -15 - 23 °C 3: 75 percent / sodium hydride / tetrahydrofuran / 3 h / Ambient temperature 4: 99 percent / hydrogen / Pd/C / ethyl acetate / 4 h 5: 83 percent / tetrabutylammonium fluoride monohydrate / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 23 p. 8574 - 8578
反应条件
1: 83 percent / triethylamine, 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 5 h / -15 - 23 °C 2: 75 percent / sodium hydride / tetrahydrofuran / 3 h / Ambient temperature 3: 99 percent / hydrogen / Pd/C / ethyl acetate / 4 h 4: 83 percent / tetrabutylammonium fluoride monohydrate / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 23 p. 8574 - 8578
反应条件
1: 99 percent / hydrogen / Pd/C / ethyl acetate / 4 h 2: 83 percent / tetrabutylammonium fluoride monohydrate / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 23 p. 8574 - 8578
反应条件
1: 75 percent / sodium hydride / tetrahydrofuran / 3 h / Ambient temperature 2: 99 percent / hydrogen / Pd/C / ethyl acetate / 4 h 3: 83 percent / tetrabutylammonium fluoride monohydrate / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 23 p. 8574 - 8578
反应条件
sodium tetrahydroborate in water T=0°C;
参考文献
Bioorganic and medicinal chemistry letters, , vol. 14, # 1 p. 275 - 278
反应条件
1: base 2: LiAlH4 / tetrahydrofuran 3: H2 / (S,S)-[(Et-DuPHOS)Rh(COD)]OTf / tetrahydrofuran / 12 h / 20 - 25 °C / 1551.44 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 36 p. 6685 - 6688
