N-Boc-L-苯丙氨醇合成路线 （共 89 条）
反应条件
1: 1.) SO3*Py 2: i-Bu2AlH, BF3*OEt2 3: N-chlorosuccinimide, Ph3P 4: 2,6-lutidine 5: AgF, (C5H5)3P, allylpalladium chloride dimer / acetonitrile / 3 h / Ambient temperature 6: 1.) 9-borabicyclo<3.3.1>nonane 2.) 30percent H2O2, 6N NaOH / 1.) THF, RT, 20 h 2.) ethanol, RT, 30 min 7: Ba(OH)2 / ethanol; H2O / 30 h / 80 °C 8: triethylamine / tetrahydrofuran / 20 h / Ambient temperature 9: 55 percent / O2 / PtO2 / dioxane; H2O / 30 h / 55 °C View Scheme
参考文献
Sakaitani, Masahiro; Ohfune, Yasufumi
Tetrahedron Letters, 1987 , vol. 28, # 34 p. 3987 - 3990
反应条件
1.1: pyridine*SO3; TEA / dimethylsulfoxide; benzene / -15 °C 2.1: H2O; ethyl acetate 2.2: 6.45 g / conc. HCl / dioxane / 8 h / Heating 3.1: 32.5 percent / TEA / tetrahydrofuran; H2O View Scheme
参考文献
Sheha, Mahmoud M.; Mahfouz, Nadia M.; Hassan, Hoda Y.; Youssef, Adel F.; Mimoto, Tsutomu; Kiso, Yoshiaki
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 10 p. 887 - 894
反应条件
1: (S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenylmethyl-1-ethanol With Dess-Martin periodane in dichloromethane 2: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in water; tert-butyl alcohol 3: diazomethyl-trimethyl-silane in methanol; toluene
参考文献
Harvey, Joanne E.; Kenworthy, Martin N.; Taylor, Richard J. K.
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2467 - 2471
反应条件
1.1: Dess-Martin periodinane / CH2Cl2 / 1.5 h / 20 °C 1.2: 2-methyl-2-butene; NaClO2; NaH2PO4 / 2-methyl-propan-2-ol; tetrahydrofuran; H2O / 1.5 h 2.1: 30 mg / toluene; methanol; diethyl ether / 0.67 h / 0 °C View Scheme
参考文献
Medina; Moyano; Pericas; Riera
Journal of Organic Chemistry, 1998 , vol. 63, # 23 p. 8574 - 8578
反应条件
Dess-Martin periodane in dichloromethane T=20°C; 2.67 h;
参考文献
US2009/42867 A1, ;
Page/Page column 33 ;
反应条件
tert.-butylnitrite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; boron trifluoride diethyl etherate in dichloromethane 24 h; Inert atmosphereReflux;
参考文献
Organic Letters, , vol. 16, # 1 p. 58 - 61
反应条件
oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine in dichloromethane T=-35 - 0°C; Oxidation; Swern oxidation;
参考文献
Journal of Organic Chemistry, , vol. 65, # 22 p. 7609 - 7611
反应条件
2,4,6-trichloro-1,3,5-triazine; dimethyl sulfoxide; triethylamine in tetrahydrofuran T=-30 - 20°C; 2.5 h;
参考文献
Journal of Organic Chemistry, , vol. 66, # 23 p. 7907 - 7909
反应条件
1: H2 / Rh-Al2O3 / 3040 Torr 2: 98.5 percent / HCl View Scheme
参考文献
Harada; Tsubaki; Kamijo; Iizuka; Kiso
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2570 - 2572
反应条件
1H-imidazole; diphenylphosphinopolystyrene; iodine in dichloromethane 1 h; Heating;
参考文献
Bolognese, Adele; Fierro, Olga; Guarino, Daniela; Longobardo, Luigi; Caputo, Romualdo
European Journal of Organic Chemistry, 2006 , # 1 p. 169 - 173
