N-Boc-L-苯丙氨醇合成路线 （共 89 条）
反应条件
5 rhodium-on-charcoal; hydrogen in methanol; water T=60°C; P=2828.7 - 3087.28 Torr; 16 h;
参考文献
Ager, David J.; Prakash, Indra
Organic Process Research and Development, 2003 , vol. 7, # 2 p. 164 - 167
反应条件
1.1: pyridine*SO3; TEA / dimethylsulfoxide; benzene / -15 °C 2.1: H2O; ethyl acetate 2.2: 6.45 g / conc. HCl / dioxane / 8 h / Heating 3.1: 32.5 percent / TEA / tetrahydrofuran; H2O View Scheme
参考文献
Sheha, Mahmoud M.; Mahfouz, Nadia M.; Hassan, Hoda Y.; Youssef, Adel F.; Mimoto, Tsutomu; Kiso, Yoshiaki
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 10 p. 887 - 894
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid; sodium hydrogencarbonate; sodium bromide in water; acetone T=20°C; 6 h;
参考文献
De Luca, Lidia; Giacomelli, Giampaolo; Masala, Simonetta; Porcheddu, Andrea
Journal of Organic Chemistry, 2003 , vol. 68, # 12 p. 4999 - 5001
反应条件
1: Et3N, DMAP / CH2Cl2 / Ambient temperature 2: dimethylformamide / 24 h / Ambient temperature 3: 6 M HCl / 12 h / Heating View Scheme
参考文献
Sutherland, Andrew; Willis, Christine L.
Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7764 - 7769
反应条件
1: triethylamine / CH2Cl2 / 1 h / 0 °C 2: LiAlH4 / tetrahydrofuran / 4 h / Heating 3: 72 percent / anhydrous potassium carbonate / acetonitrile / 12 h / 25 °C View Scheme
参考文献
Tetrahedron, , vol. 63, # 39 p. 9758 - 9763
反应条件
triethylamine in dichloromethane T=0°C; 0.33 h;
参考文献
Gooding, Owen W.; Lindberg, Thomas; Miller, Wendy; Munyak, Edward; Vo, Lanchi
Organic Process Research and Development, 2001 , vol. 5, # 3 p. 283 - 293
反应条件
triethylamine in tetrahydrofuran T=0°C; 0.5 h;
参考文献
ALCON MANUFACTURING, LTD.
Patent: US2007/149548 A1, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
1: NBS, Ph3P / CH2Cl2 / 2 h / 0 °C 2: NaN3 / dimethylformamide / 24 h / 60 °C 3: H2 / Lindlar catalyst / methanol / 16 h / 760 Torr / Ambient temperature View Scheme
参考文献
O'Brien; Sliskovic; Blankley; Roth; Wilson; Hamelehle; Krause; Stanfield
Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1810 - 1822
反应条件
1.1: Dess-Martin periodinane / CH2Cl2 / 1.5 h / 20 °C 1.2: 2-methyl-2-butene; NaClO2; NaH2PO4 / 2-methyl-propan-2-ol; tetrahydrofuran; H2O / 1.5 h 2.1: 30 mg / toluene; methanol; diethyl ether / 0.67 h / 0 °C 3.1: HCl; anisole / H2O / 5 h / 70 °C View Scheme
参考文献
Harvey, Joanne E.; Kenworthy, Martin N.; Taylor, Richard J. K.
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2467 - 2471
反应条件
1: pyridine / CHCl3 / 22 h 2: 80 percent / dimethylformamide / 22 h / 55 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 13 p. 2629 - 2632
