N-Boc-L-苯丙氨醇合成路线 （共 89 条）
反应条件
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C 1.2: 2 h / 60 °C 2.1: AlCl3, aluminium chloride / 22 h / -5 °C 2.2: 35 - 50 °C 2.3: 18 h / 65 °C 3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C 4.1: tetrabutylammomium bromide; sodium hydrogencarbonate / acetonitrile / 26 h / Reflux; Large scale reaction View Scheme
参考文献
Bellingham, Richard; Buswell, A. Mark; Choudary, Bernie M.; Gordon, Andrew H.; Moore, Steve O.; Peterson, Matthew; Sasse, Mike; Shamji, Amin; Urquhart, Michael W. J.
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1254 - 1263
反应条件
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C 1.2: 2 h / 60 °C 2.1: AlCl3, aluminium chloride / 22 h / -5 °C 2.2: 35 - 50 °C 2.3: 18 h / 65 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 14, # 5 p. 1254 - 1263
反应条件
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C
1.2: 2 h / 60 °C
2.1: AlCl3, aluminium chloride / 22 h / -5 °C
2.2: 35 - 50 °C
2.3: 18 h / 65 °C
3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C
4.1: tetrabutylammomium bromide; sodium hydrogencarbonate / acetonitrile / 26 h / Reflux; Large scale reaction
5.1: hydrazine hydrate / ethanol; tert-butyl methyl ether / 16 h / 40 °C
5.2: 40 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C
View Scheme
参考文献
Bellingham, Richard; Buswell, A. Mark; Choudary, Bernie M.; Gordon, Andrew H.; Moore, Steve O.; Peterson, Matthew; Sasse, Mike; Shamji, Amin; Urquhart, Michael W. J.
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1254 - 1263
反应条件
triethylamine in dichloromethane
T=0°C; 0.33 h;
参考文献
Gooding, Owen W.; Lindberg, Thomas; Miller, Wendy; Munyak, Edward; Vo, Lanchi
Organic Process Research and Development, 2001 , vol. 5, # 3 p. 283 - 293
反应条件
triethylamine in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
ALCON MANUFACTURING, LTD.
Patent: US2007/149548 A1, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C
1.2: 2 h / 60 °C
2.1: AlCl3, aluminium chloride / 22 h / -5 °C
2.2: 35 - 50 °C
2.3: 18 h / 65 °C
3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C
4.1: tetrabutylammomium bromide; sodium hydrogencarbonate / acetonitrile / 26 h / Reflux; Large scale reaction
5.1: hydrazine hydrate / ethanol; tert-butyl methyl ether / 16 h / 40 °C
5.2: 40 °C
View Scheme
参考文献
Bellingham, Richard; Buswell, A. Mark; Choudary, Bernie M.; Gordon, Andrew H.; Moore, Steve O.; Peterson, Matthew; Sasse, Mike; Shamji, Amin; Urquhart, Michael W. J.
Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1254 - 1263
反应条件
1: Et3N, DMAP / CH2Cl2 / Ambient temperature
2: dimethylformamide / 24 h / Ambient temperature
3: 6 M HCl / 12 h / Heating
View Scheme
参考文献
Sutherland, Andrew; Willis, Christine L.
Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7764 - 7769
反应条件
ammonium chloride in tetrahydrofuran; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
British Bio-Technology Limited
Patent: US5180723 A1, 1993 ;
反应条件
1.1: Dess-Martin periodinane / CH2Cl2
1.2: NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O
1.3: 75 percent / toluene; methanol
2.1: Dess-Martin periodinane / CH2Cl2
2.2: NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O
2.3: 51 percent / toluene; methanol
View Scheme
参考文献
Harvey, Joanne E.; Kenworthy, Martin N.; Taylor, Richard J. K.
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2467 - 2471
