N-[(1S)-1-(羟基甲基)-2-[4-(苯基甲氧基)苯基]乙基]-氨基甲酸叔丁酯合成路线 （共 15 条）
反应条件
1: 90 percent / pyridine / Ambient temperature 2: 23 percent / aq. K2S2O8, aq. CuSO4 / acetonitrile / 1.67 h / Heating View Scheme
参考文献
Kawamine; Takeuchi; Miyashita; Irie; Shimamoto; Ohfune
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3170 - 3171
反应条件
diborane
T=-10 - 25°C; 6 h; Inert atmosphere;
参考文献
Mavridis, Ioannis; Kythreoti, Georgia; Koltsida, Konstantina; Vourloumis, Dionisios
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1329 - 1341
反应条件
sodium tetrahydroborate; lithium iodide in tetrahydrofuran
2 h; Heating;
参考文献
Richter, Jeremy M.; Whitefield, Brandon W.; Maimone, Thomas J.; Lin, David W.; Castroviejo, M. Pilar; Baran, Phil S.
Journal of the American Chemical Society, 2007 , vol. 129, # 42 p. 12857 - 12869
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C; 1.75 h;
参考文献
Green, Rachel; Taylor, Piers J. M.; Bull, Steven D.; James, Tony D.; Mahon, Mary F.; Merritt, Andy T.
Tetrahedron Asymmetry, 2003 , vol. 14, # 17 p. 2619 - 2623
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C;
参考文献
He, Xiping; Li, Jia; Lu, Cuifen; Chen, Zuxin; Yang, Guichun
Canadian Journal of Chemistry, 2011 , vol. 89, # 1 p. 88 - 91
反应条件
tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide
参考文献
The Scripps Research Institute
Patent: US5455271 A1, 1995 ;
US 5455271 A
反应条件
sodium tetrahydroborate in ethylene glycol dimethyl ether; water
0.166667 h; Ambient temperature;
参考文献
Fehrentz, Jean-Alain; Califano, Jean-Christophe; Amblard, Muriel; Loffet, Albert; Martinez, Jean
Tetrahedron Letters, 1994 , vol. 35, # 4 p. 569 - 572
反应条件
1: thionyl chloride / 20 h / Heating
2: triethylamine / methanol / 17 h / 20 °C
3: 100 percent / potassium carbonate; potassium iodide / acetone / 4 h / Heating
4: 87 percent / sodium borohydride; lithium iodide / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Oila, Markku J.; Tois, Jan E.; Koskinen, Ari M.P.
Tetrahedron, 2005 , vol. 61, # 45 p. 10748 - 10756
反应条件
1: 87 percent / potassium carbonate; tetrabutylammonium iodide / dimethylformamide / 48 h / 20 °C
2: 88 percent / LiAlH4 / tetrahydrofuran / 1.75 h / 0 - 20 °C
View Scheme
参考文献
Green, Rachel; Taylor, Piers J. M.; Bull, Steven D.; James, Tony D.; Mahon, Mary F.; Merritt, Andy T.
Tetrahedron Asymmetry, 2003 , vol. 14, # 17 p. 2619 - 2623
反应条件
1: triethylamine / methanol / 17 h / 20 °C
2: 100 percent / potassium carbonate; potassium iodide / acetone / 4 h / Heating
3: 87 percent / sodium borohydride; lithium iodide / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Oila, Markku J.; Tois, Jan E.; Koskinen, Ari M.P.
Tetrahedron, 2005 , vol. 61, # 45 p. 10748 - 10756
