N-[(1S)-1-(羟基甲基)-2-[4-(苯基甲氧基)苯基]乙基]-氨基甲酸叔丁酯合成路线 （共 15 条）
反应条件
1: 100 percent / potassium carbonate; potassium iodide / acetone / 4 h / Heating
2: 87 percent / sodium borohydride; lithium iodide / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Oila, Markku J.; Tois, Jan E.; Koskinen, Ari M.P.
Tetrahedron, 2005 , vol. 61, # 45 p. 10748 - 10756
反应条件
1: 18-crown-6 ether; potassium carbonate / N,N-dimethyl-formamide / 24 h / 40 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
He, Xiping; Li, Jia; Lu, Cuifen; Chen, Zuxin; Yang, Guichun
Canadian Journal of Chemistry, 2011 , vol. 89, # 1 p. 88 - 91
反应条件
1: aq. NaOH; NaHCO3 / dioxane / 20 °C
2: N-methylmorpholine / tetrahydrofuran / -15 °C
3: NaBH4 / methanol; tetrahydrofuran / 1.5 h
View Scheme
参考文献
Caplar, Vesna; Raza, Zlata; Katalenic, Darinka; Zinic, Mladen
Croatica Chemica Acta, 2003 , vol. 76, # 1 p. 23 - 36
反应条件
1: aq. NaOH; NaHCO3 / dioxane / 20 °C
2: N-methylmorpholine / tetrahydrofuran / -15 °C
3: NaBH4 / methanol; tetrahydrofuran / 1.5 h
View Scheme
参考文献
Caplar, Vesna; Raza, Zlata; Katalenic, Darinka; Zinic, Mladen
Croatica Chemica Acta, 2003 , vol. 76, # 1 p. 23 - 36
反应条件
toluene-4-sulfonic acid in tetrahydrofuran; dichloromethane
pH=13; 6 h; Heating;
参考文献
Richter, Jeremy M.; Whitefield, Brandon W.; Maimone, Thomas J.; Lin, David W.; Castroviejo, M. Pilar; Baran, Phil S.
Journal of the American Chemical Society, 2007 , vol. 129, # 42 p. 12857 - 12869
