5-甲氧基-3-(1,2,3,6-四氢-4-吡啶)-1H-吲哚合成路线 (共 8 条)
反应条件
potassium hydroxide in ethanol
Heating / reflux;
参考文献
BIO-MEDISINSK INNOVASJON AS; COCKBAIN, Julian
Patent: WO2007/7072 A1, 2007 ;
Location in patent: Page/Page column 21-22 ;
WO 2007/007072 A1
参考文献
Roussel Uclaf
Patent: US4196209 A1, 1980 ;
参考文献
Roussel Uclaf
Patent: US4232031 A1, 1980 ;
参考文献
Eli Lilly and Company
Patent: US5614523 A1, 1997 ;
US 5614523 A
参考文献
Eli Lilly and Company
Patent: US5846982 A1, 1998 ;
US 5846982 A
反应条件
in acetic acid
T=100°C; 0.5 h;
参考文献
Guillaume; Dumont; Laurent; Nedelec
European Journal of Medicinal Chemistry, 1987 , vol. 22, # 1 p. 33 - 43
反应条件
phosphoric acid; acetic acid
T=80°C;
参考文献
Mattsson, Cecilia; Sonesson, Clas; Sandahl, Anna; Greiner, Hartmut E.; Gassen, Michael; Plaschke, Joerg; Leibrock, Joachim; Boettcher, Henning
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4230 - 4234
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
P=760.051 Torr; 24 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/6922 A1, 2004 ;
Location in patent: Page/Page column 38 ;