N-叔丁氧羰基-L-苯丙氨酸苄酯合成路线 （共 22 条）
反应条件
1: 81 percent / 1 M NaOH / tetrahydrofuran / 1 h / Ambient temperature
2: 84 percent / pyridine / 24 h / -10 °C
3: 80 percent / NaI / acetone / 24 h / Ambient temperature
4: 1) zinc-copper couple / 2) bis(tri-o-tolylphosphine)palladium trichloride / 1) DMA, benzene, sonication, 30 min, 2) DMA, benzene, 50 deg C, 1 h
View Scheme
参考文献
Jackson, Richard F. W.; Wishart, Neil; Wood, Anthony; James, Keith; Wythes, Martin J.
Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3397 - 3404
反应条件
potassium carbonate in dichloromethane
8 h; Ambient temperature;
参考文献
Nakata, Takashi; Nakatani, Masaru; Takahashi, Masatoshi; Okai, Jiro; Kawaoka, Yoshiaki; Kouge, Katsushige; Okai, Hideo
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 4 p. 1099 - 1106
反应条件
1: 81 percent / 1 M NaOH / tetrahydrofuran / 1 h / Ambient temperature
2: 84 percent / pyridine / 24 h / -10 °C
3: 80 percent / NaI / acetone / 24 h / Ambient temperature
4: 1) zinc-copper couple / 2) bis(tri-o-tolylphosphine)palladium trichloride / 1) DMA, benzene, sonication, 30 min, 2) DMA, benzene, 50 deg C, 1 h
View Scheme
参考文献
Jackson, Richard F. W.; Wishart, Neil; Wood, Anthony; James, Keith; Wythes, Martin J.
Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3397 - 3404
反应条件
1: 84 percent / pyridine / 24 h / -10 °C
2: 80 percent / NaI / acetone / 24 h / Ambient temperature
3: 1) zinc-copper couple / 2) bis(tri-o-tolylphosphine)palladium trichloride / 1) DMA, benzene, sonication, 30 min, 2) DMA, benzene, 50 deg C, 1 h
View Scheme
参考文献
Jackson, Richard F. W.; Wishart, Neil; Wood, Anthony; James, Keith; Wythes, Martin J.
Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3397 - 3404
反应条件
1: 80 percent / NaI / acetone / 24 h / Ambient temperature
2: 1) zinc-copper couple / 2) bis(tri-o-tolylphosphine)palladium trichloride / 1) DMA, benzene, sonication, 30 min, 2) DMA, benzene, 50 deg C, 1 h
View Scheme
参考文献
Jackson, Richard F. W.; Wishart, Neil; Wood, Anthony; James, Keith; Wythes, Martin J.
Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3397 - 3404
反应条件
1: 74 percent / CCl4 / 8 h / Heating
2: 81 percent / 1 M NaOH / tetrahydrofuran / 1 h / Ambient temperature
3: 84 percent / pyridine / 24 h / -10 °C
4: 80 percent / NaI / acetone / 24 h / Ambient temperature
5: 1) zinc-copper couple / 2) bis(tri-o-tolylphosphine)palladium trichloride / 1) DMA, benzene, sonication, 30 min, 2) DMA, benzene, 50 deg C, 1 h
View Scheme
参考文献
Jackson, Richard F. W.; Wishart, Neil; Wood, Anthony; James, Keith; Wythes, Martin J.
Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3397 - 3404
反应条件
in N,N-dimethyl-formamide
参考文献
Gunnarsson, Kerstin; Ragnarsson, Ulf
Acta Chemica Scandinavica, 1990 , vol. 44, # 7 p. 944 - 951
反应条件
sodium ethanolate in dichloromethane
T=25°C; 18 h; Yield given;
参考文献
Drew, Michael G. B.; Gorsuch, Stephen; Mann, John; Yoshida, Shimon
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1627 - 1636
反应条件
1: CH2Cl2 / 0.08 h
2: NaOEt / CH2Cl2 / 18 h / 25 °C
View Scheme
参考文献
Drew, Michael G. B.; Gorsuch, Stephen; Mann, John; Yoshida, Shimon
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1627 - 1636
反应条件
1: sodium hydroxide / methanol
2: tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium iodide / acetone
View Scheme
参考文献
Yang, Kanghui; Fen, Jinghong; Fang, Hao; Zhang, Lei; Gong, Jianzhi; Xu, Wenfang
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 2 p. 302 - 310
