2,3-二氢-1H-吡呤-1,7-二羧酸合成路线 （共 9 条）
反应条件
potassium hydroxide in methanol; water
3 h; Heating;
参考文献
Carpio; Galeazzi; Greenhouse; et al.
Canadian Journal of Chemistry, 1982 , vol. 60, # 18 p. 2295 - 2312
反应条件
sodium hydroxide in tetrahydrofuran; hexane
参考文献
Syntex Inc.
Patent: US4835288 A1, 1989 ;
反应条件
sodium hydroxide in tetrahydrofuran; hexane
参考文献
Syntex Inc.
Patent: US4835288 A1, 1989 ;
反应条件
1: 0-10 deg C
2: acetonitrile / 1 h / Heating
3: 99 percent / triethylamine / CH2Cl2 / 1 h / -10 - -5 °C
4: 90 percent / NaI / acetonitrile / 1 h / Heating
5: 95 percent / NaH / dimethylformamide / 1 h / 0 deg C -> r.t.
6: 89 percent / 85percent KOH / methanol; H2O / 3 h / Heating
View Scheme
参考文献
Carpio; Galeazzi; Greenhouse; et al.
Canadian Journal of Chemistry, 1982 , vol. 60, # 18 p. 2295 - 2312
反应条件
1: 99 percent / triethylamine / CH2Cl2 / 1 h / -10 - -5 °C
2: 90 percent / NaI / acetonitrile / 1 h / Heating
3: 95 percent / NaH / dimethylformamide / 1 h / 0 deg C -> r.t.
4: 89 percent / 85percent KOH / methanol; H2O / 3 h / Heating
View Scheme
参考文献
Carpio; Galeazzi; Greenhouse; et al.
Canadian Journal of Chemistry, 1982 , vol. 60, # 18 p. 2295 - 2312
反应条件
1: 95 percent / NaH / dimethylformamide / 1 h / 0 deg C -> r.t.
2: 89 percent / 85percent KOH / methanol; H2O / 3 h / Heating
View Scheme
参考文献
Carpio; Galeazzi; Greenhouse; et al.
Canadian Journal of Chemistry, 1982 , vol. 60, # 18 p. 2295 - 2312
反应条件
1: 90 percent / NaI / acetonitrile / 1 h / Heating
2: 95 percent / NaH / dimethylformamide / 1 h / 0 deg C -> r.t.
3: 89 percent / 85percent KOH / methanol; H2O / 3 h / Heating
View Scheme
参考文献
Carpio; Galeazzi; Greenhouse; et al.
Canadian Journal of Chemistry, 1982 , vol. 60, # 18 p. 2295 - 2312
反应条件
1: acetonitrile / 1 h / Heating
2: 99 percent / triethylamine / CH2Cl2 / 1 h / -10 - -5 °C
3: 90 percent / NaI / acetonitrile / 1 h / Heating
4: 95 percent / NaH / dimethylformamide / 1 h / 0 deg C -> r.t.
5: 89 percent / 85percent KOH / methanol; H2O / 3 h / Heating
View Scheme
参考文献
Carpio; Galeazzi; Greenhouse; et al.
Canadian Journal of Chemistry, 1982 , vol. 60, # 18 p. 2295 - 2312
反应条件
1: 91 percent / HCl / 1.5 h / 0 -> 25 deg C
2: 68 percent / 1 h / 270 °C
View Scheme
参考文献
Carpio; Galeazzi; Greenhouse; et al.
Canadian Journal of Chemistry, 1982 , vol. 60, # 18 p. 2295 - 2312
