3-甲基-alpha-氧代-苯乙酸乙酯合成路线 (共 7 条)
反应条件
1: 1-bromo-3-methyl-benzene With magnesium in tetrahydrofuran T=20°C; 1 h; Inert atmosphere; 2: oxalic acid diethyl ester in tetrahydrofuran T=-78°C; 2 h; Inert atmosphere;
参考文献
Hayashi, Masashi; Nakamura, Shuichi
Angewandte Chemie - International Edition, 2011 , vol. 50, # 10 p. 2249 - 2252
反应条件
1: 1-chloro-3-methylbenzene With lithium in diethyl ether T=3 - 6°C; 2: With copper (I) cyanide in tetrahydrofuran; diethyl ether T=3 - 6°C; 0.416667 h; Cooling with ice; 3: oxalic acid monoethyl ester chloride in tetrahydrofuran; diethyl ether T=3 - 20°C; 1.25 h;
参考文献
Screttas, Constantinos G.; Steele, Barry R.; Micha-Screttas, Maria; Heropoulos, Georgios A.
Organic Letters, 2012 , vol. 14, # 22 p. 5680 - 5683
参考文献
Chemische Berichte, , vol. 56, p. 1624
参考文献
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 248, p. 3314
参考文献
Chemische Berichte, , vol. 56, p. 1624
反应条件
1: concentrated hydrochloric acid 2: bei der Destillation View Scheme
参考文献
Posner; Heumann
Chemische Berichte, 1923 , vol. 56, p. 1624
反应条件
1: concentrated hydrochloric acid 2: bei der Destillation View Scheme
参考文献
Chemische Berichte, , vol. 56, p. 1624